Study on the Effect of Capacity Shock Intervention Under Goal-directed Hemodynamic Management on P-V Loop-based Myocardial Contraction and Work
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Ea
研究概览
简要总结
By observing the changes of P-V loop in capacity shock intervention Under Goal-directed Hemodynamic Management in patients undergoing total knee replacement, we investigate the effect of capacity shock on cardiac contractility and work in order to seek a more effective target plan of capacity shock for intraoperative patients.
详细描述
Objective
By observing the changes of P-V loop in capacity shock intervention Under Goal-directed Hemodynamic Management in patients undergoing total knee replacement, we investigate the effect of capacity shock on cardiac contractility and work in order to seek a more effective target plan of capacity shock for intraoperative patients.
Methods:20 patients with total knee replacement were enrolled in this study. Capacity shock therapy was used in Group A(n=10) and conventional strategy was used in Group B (n=10). V(t) was measured and calculated using TEE and P(t) was acquired by the analysis of patients'radial artery pressure waveform. We set five time points of parameter acquisition: after grouping (T1), the first shock completion(T2), the second shock completion (T3), 1h after shock treatment (T4), and operation completion(T5). We make up the P-V loop fitting P(t) and V(t) at each time point after the calibration of cardiac cycle.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •ASAI-II age 40- 70 weight 48 - 72 kg.
排除标准
- •Body mass index >30 or <15 kg/m2 Valve heart disease Left ventricular ejection fraction (LVEF) is less than 50% History of lung disease Preoperative arrhythmic disorder Permanent pacemaker Need for mechanical heart Support, Severe extrinsic vascular disease Valve dysfunction OED monitoring probe insertion contraindications Patients with preoperative assessments
研究组 & 干预措施
capacity shock
2ml/kg succinylateol gelatin
干预措施: Fluid challenge strategy (Procedure)
routine management
conventional strategy
干预措施: conventional strategy (Procedure)
结局指标
主要结局
Ea
时间窗: At the end of surgery
Ea(Arterial elasticity, mmHg·ml)
SW
时间窗: At the end of surgery
SW（Stroke Volume，mmHg·ml）
Ees
时间窗: At the end of surgery
Ees（End-systole Elasticity，mmHg/ml）
Ea
时间窗: Baseline，after induction
Ea(Arterial elasticity, mmHg·ml)
Ees
时间窗: Baseline，After induction
Ees（End-systole Elasticity，mmHg/ml）
Ees
时间窗: Immediately after the intervention,complete of the first round of the fluid challenge
Ees（End-systole Elasticity，mmHg/ml）
Ees
时间窗: Immediately after the intervention,complete of the second round of the fluid challenge
Arterial elasticity is an invasively determined parameter of arterial load that is inversely related to arterial compliance
Ees
时间窗: 1h after the first fluid challenge
Ees（End-systole Elasticity，mmHg/ml）
SW
时间窗: Baseline，after induction
SW（Stroke Volume，mmHg·ml）
SW
时间窗: Immediately after the intervention,complete of the first round of the fluid challenge
SW（Stroke Volume，mmHg·ml）
SW
时间窗: Immediately after the intervention,complete of the second round of the fluid challenge
SW（Stroke Volume，mmHg·ml）
SW
时间窗: 1h after the first fluid challenge
SW（Stroke Volume，mmHg·ml）
Ea
时间窗: Immediately after the intervention,complete of the first round of the fluid challenge
Ea(Arterial elasticity, mmHg·ml)
Ea
时间窗: Immediately after the intervention,complete of the second round of the fluid challenge
Ea(Arterial elasticity, mmHg·ml)
Ea
时间窗: 1h after the first fluid challenge
Ea(Arterial elasticity, mmHg·ml)
次要结局
未报告次要终点
研究者
Liang Bing
Deputy Director of Anesthesiology Physicians
Guangzhou Red Cross Hospital