Short-Term Response of Serum Brain-Derived Neurotrophic Factor to Repetitive Transcranial Magnetic Stimulation in Patients With Chronic Schizophrenia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 21
- 试验地点
- 2
- 主要终点
- change from baseline of serum BDNF concentration
研究概览
简要总结
This study aims at investigating the neuroplastic potential and the possible factors affecting rehabilitation in chronic schizophrenia patients on stable medication, by investigating the cumulative pattern of serum BDNF representing the neuroplasticity in the brain, through quantitative stimulus such as rTMS.
详细描述
Subjects who have been enrolled for this study will take baseline evaluation for sociodemographic data and serum level of BDNF, plasma Prolaction, and magnesium, etc. And then, weekday regular stimulation through rTMS will be applied on DLPFC of brain. After the completion of stimulation for 2 weeks, the change or response of serum BDNF will be analyzed and compared.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •duration of illness over 10 years
- •on stable medication, antipsychotics
- •no change on medication within at least 2 weeks
- •Diagnosis of Schizophrenia according to DSM-IV-TR
排除标准
- •left or both-handedness
- •anticonvulsant use
- •lorazepam equivalent over 3 mg
结局指标
主要结局
change from baseline of serum BDNF concentration
时间窗: baseline-1 week-2 week-4 week
次要结局
未报告次要终点
研究者
HWANG TAEYOUNG
Director, Insan Research Center for Psychiatry
Jeonbuk Provincial Maeumsarang Hospital