Effects of withdrawing diuretic therapy (thiazide or loop), used for the treatment of hypertension, on glucose metabolism in subjects with normal glucose tolerance, pre-diabetes or type 2 diabetes: a randomized controlled trial

niversity of Palermo (Italy)0 个研究点目标入组 80 人开始时间: 2013年8月1日最近更新: 2015年1月13日

适应症

试验速览

暂无简介。

•1. Male and female subjects
•2. Aged 30-80 years
•3. Having hypertension for less than 15 years
•4. Basal blood pressure <140/90 mmHg
•5. Non diabetics or having diabetes for less than 15 years
•6. Using at least one of the following diuretics for more than 6 months: furosemide, torasemide, hydrochlorothiazide, chlorthalidone

•1. Average 24 hour blood pressure from ambulatory blood pressure monitoring > 160/90 mmHg
•2. Concomitant use of >3 anti-hypertensives
•3. Habitual use of indapamide, spironolactone, calcium channel blockers
•4. Habitual use of FANS, corticosteroids, litium salts
•5. Allergy or intolerance versus calcium-channel blockers
•6. Self monitoring average glycemia > 250 mg/dl
•7. Glycated hemoglobin > 86 mol/mol
•8. Habitual smokers: more than 10 cigarette/day
•9. Habitual use of super-alcoholics or wine more than 1 glass/day
•10. Secondary hypertension, congestive heart failure, liver cirrhosis, chronic renal failure (calculated -CKEPI, MDRD - GFR< 40 ml/min/1.73 m2)
•11. Connective diseases
•12. Severe gastro-oesophageal reflux with Barrett's esofagus
•13. Atrioventricular conduction defects
•14. Pregnancy or lactation in the last six months
•15. Denial of informed consent

发起方

niversity of Palermo (Italy)