A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)
- Conditions
- Early Breast Cancer
- Interventions
- Registration Number
- NCT04961996
- Lead Sponsor
- Hoffmann-La Roche
- Brief Summary
This is a Phase III, global, randomized, open-label, multicenter, study evaluating the efficacy and safety of adjuvant giredestrant compared with endocrine therapy of physician's choice in participants with medium- and high-risk Stage I-III histologically confirmed estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative early breast cancer.
In addition, an open-label exploratory substudy will explore the safety and efficacy of giredestrant in combination with abemaciclib in a subset of the primary study population.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 4200
- Documented estrogen receptor (ER)-positive and HER2-negative breast tumor, as assessed locally on a primary disease specimen
- Participants who have multicentric (the presence of two of more tumor foci within different quadrants of the same breast) and/or multifocal (the presence of two or more tumor foci within a single quadrant of the breast) breast cancer are also eligible if all examined tumors meet pathologic criteria for ER positivity and HER2 negativity
- Participants must have undergone definitive surgery of their primary breast tumor(s) and axillary lymph nodes (axillary lymph node dissection [ALND] and/or sentinel lymph node biopsy [SLNB])
- Participants who received or will be receiving adjuvant chemotherapy must have completed adjuvant chemotherapy prior to randomization. Participants may also have received neoadjuvant chemotherapy. A washout period of at least 21 days is required between last adjuvant chemotherapy dose and randomization.
- Resolution of all acute toxic effects of prior anti-cancer therapy or surgical procedures to NCI CTCAE v5.0 Grade 1 or better (except alopecia, Grade ≤2 peripheral neuropathy, arthralgia or other toxicities not considered a safety risk for the participant per the investigator's judgment)
- Participants have received (neo)adjuvant chemotherapy and/or had surgery and had no prior endocrine therapy are eligible, provided that they are enrolled within 12 months following definitive breast cancer surgery
- Participants who have confirmed availability of an untreated primary breast tumor tissue specimen suitable for biomarker testing (i.e., representative archived formalin-fixed, paraffin-embedded [FFPE] tissue block [preferred] or 15-20 slides containing unstained, freshly cut, serial sections), with associated de-identified pathology report is required. Although 15-20 slides are preferred, if only 10-14 slides are available, the individual may still be eligible for the study.
- Participants with node-positive and node-negative disease are eligible provided they meet additional risk criteria as defined in the protocol
- Eastern Cooperative Oncology Group (ECOG) Performance Status 0, 1, or 2
- Able and willing to swallow, retain, and absorb oral medication
- Adequate organ function
Substudy Inclusion Criteria:
To be eligible for substudy participation, in addition to meeting the inclusion criteria in the primary protocol, participants must also meet the following modified criteria:
- Patients who received adjuvant radiotherapy must have completed radiotherapy prior to enrollment, and patients must have recovered (to Grade ≤1) from the acute effects of radiotherapy. A washout period of at least 14 days is required between end of radiotherapy and enrollment.
Primary Study
- Pregnant or breastfeeding, or intending to become pregnant during the study or within 10 days after the final dose of giredestrant, or within the time period specified per local prescribing guidelines after the final dose of the endocrine therapy of physician's choice
- Received treatment with investigational therapy within 28 days prior to initiation of study treatment or is currently enrolled in any other type of medical research judged by the sponsor not to be scientifically or medically compatible with this study
- Receiving or planning to receive a CDK4/6 inhibitor as (neo)adjuvant therapy. A short course of up to 12 weeks of neoadjuvant or adjuvant treatment with CDK4/6 inhibitor therapy prior to randomization is allowed.
- Active cardiac disease or history of cardiac dysfunction
- Diagnosed with Stage IV breast cancer
- A history of any prior (ipsilateral and/or contralateral) invasive breast cancer or ductal carcinoma in situ (DCIS). Participants with a history of contralateral DCIS treated by only local regional therapy at any time may be eligible.
- A history of any other malignancy within 3 years prior to screening, except for appropriately treated carcinoma in situ of the cervix, nonmelanoma skin carcinoma, or Stage I uterine cancer
- Any prior endocrine treatment with selective ER modulators (e.g., tamoxifen), degraders, or aromatase inhibitors. A short course of neoadjuvant or adjuvant endocrine therapy (up to 12 weeks) is allowed.
- Clinically significant liver disease consistent with Child-Pugh Class B or C, including active hepatitis (e.g., hepatitis B virus [HBV] or hepatitis C virus [HCV]), current alcohol abuse, cirrhosis, or positive test for viral hepatitis
- Treatment with strong CYP3A4 inhibitors or inducers within 14 days or 5 drug elimination half-lives (whichever is longer) prior to initiation of study treatment
- Known allergy or hypersensitivity to any of the study drugs or any of their excipients
- Pre- and perimenopausal participants or male participants who have a known hypersensitivity to LHRH agonists
- A documented history of hemorrhagic diathesis, coagulopathy, or thromboembolism
- Renal dysfunction that requires dialysis
- A major surgical procedure unrelated to breast cancer within 28 days prior to randomization
- A serious infection requiring oral or IV antibiotics within 14 days prior to screening or other clinically significant infection (e.g., COVID-19) within 14 days prior to screening
- Any serious medical condition or abnormality in clinical laboratory tests that, in the investigator's judgment, precludes an individual's safe participation in and completion of the study
- Unable or unwilling to comply with the requirements of the protocol in the opinion of the investigator
Substudy Exclusion Criteria:
Potential participants are excluded from the substudy if any criteria from t\he primary study or the following criteria apply:
- Prior participation in the GO42784 primary study
- Received a CDK4/6i as (neo)adjuvant therapy prior to enrollment
- Treatment with moderate CYP3A inducers, strong CYP3A inducers or strong CYP3A inhibitors within 14 days or 5 drug elimination half-lives (whichever is longer) prior to initiation of study treatment
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Arm A: Giredestrant LHRH Agonist - Arm A: Giredestrant Giredestrant - Arm B: Endocrine Therapy of Physician's Choice Endocrine Therapy of Physician's Choice - Arm B: Endocrine Therapy of Physician's Choice LHRH Agonist - Substudy: Giredestrant + Abemaciclib, Then Giredestrant Giredestrant In this substudy, participants will receive giredestrant in combination with abemaciclib for up to 2 years. Participants will continue with giredestrant monotherapy for an additional 3 years in order to complete a total of 5 years on study treatment. Substudy: Giredestrant + Abemaciclib, Then Giredestrant Abemaciclib In this substudy, participants will receive giredestrant in combination with abemaciclib for up to 2 years. Participants will continue with giredestrant monotherapy for an additional 3 years in order to complete a total of 5 years on study treatment.
- Primary Outcome Measures
Name Time Method Invasive Disease-Free Survival (IDFS), Excluding Second Primary Non-Breast Cancers From randomization to first occurrence of an IDFS event (up to 10 years)
- Secondary Outcome Measures
Name Time Method Change from Baseline in the Mean Global Health Status/Quality of Life (QoL) Scale Score at Specified Timepoints, Assessed Using the EORTC QLQ-C30 Baseline (Cycle 1) and Cycles 3, 6, 9, 12, 15, 18, 21, 24, 30, 36, 42, 48, 54, and 60 (1 cycle is 28 days) of treatment, once every 6 months during the first 2 years of post-treatment follow-up and annually for 3 years thereafter (up to 10 years) Invasive Disease-Free Survival (IDFS), Including Second Primary Non-Breast Cancers From randomization to first occurrence of an IDFS event (up to 10 years) Change from Baseline in the Mean Role Functioning Scale Score at Specified Timepoints, Assessed Using the EORTC QLQ-C30 Baseline (Cycle 1) and Cycles 3, 6, 9, 12, 15, 18, 21, 24, 30, 36, 42, 48, 54, and 60 (1 cycle is 28 days) of treatment, once every 6 months during the first 2 years of post-treatment follow-up and annually for 3 years thereafter (up to 10 years) Distant Recurrence-Free Interval (DRFI) From randomization to first occurrence of a DFRI event (up to 10 years) Change from Baseline in the Mean Physical Functioning Scale Score at Specified Timepoints, Assessed Using the EORTC QLQ-C30 Baseline (Cycle 1) and Cycles 3, 6, 9, 12, 15, 18, 21, 24, 30, 36, 42, 48, 54, and 60 (1 cycle is 28 days) of treatment, once every 6 months during the first 2 years of post-treatment follow-up and annually for 3 years thereafter (up to 10 years) Change from Baseline in the EQ 5D-5L Index-Based Score at Specified Timepoints Baseline (Cycle 1) and Cycles 3, 6, 9, 12, 15, 18, 21, 24, 30, 36, 42, 48, 54, and 60 (1 cycle is 28 days) of treatment, once every 6 months during the first 2 years of post-treatment follow-up and annually for 3 years thereafter (up to 10 years) Incidence and Severity of Adverse Events, with Severity Determined According to National Cancer Institute Common Terminology Criteria for Adverse Events, version 5.0 (NCI-CTCAE v5.0) From start of treatment until 28 days after the final dose of study treatment (up to 5 years) Substudy: Incidence of Grade ≥3 Adverse Events with Giredestrant in Combination with Abemaciclib From first dose of study treatment until 28 days after the last dose of treatment with the combination of giredestrant and abemaciclib or until the end of Year 2, whichever occurs first (up to 2 years) Overall Survival From randomization to death from any cause (up to 10 years) Plasma Concentrations of Giredestrant at Specified Timepoints Predose and 3-4 hours postdose on Day 1 of Cycles 1 and 2, and predose on Day 1 of Cycles 3 and 6 (1 cycle is 28 days) Disease-Free Survival (DFS) From randomization to first occurrence of a DFS event (up to 10 years) Locoregional Recurrence-Free Interval (LRRFI) From randomization to first occurrence of a LRRFI event (up to 10 years) Mean Physical Functioning Scale Score at Specified Timepoints, Assessed Using the European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) Baseline (Cycle 1) and Cycles 3, 6, 9, 12, 15, 18, 21, 24, 30, 36, 42, 48, 54, and 60 (1 cycle is 28 days) of treatment, once every 6 months during the first 2 years of post-treatment follow-up and annually for 3 years thereafter (up to 10 years) Mean Role Functioning Scale Score at Specified Timepoints, Assessed Using the EORTC QLQ-C30 Baseline (Cycle 1) and Cycles 3, 6, 9, 12, 15, 18, 21, 24, 30, 36, 42, 48, 54, and 60 (1 cycle is 28 days) of treatment, once every 6 months during the first 2 years of post-treatment follow-up and annually for 3 years thereafter (up to 10 years) Change from Baseline in the EQ 5D-5L Visual Analogue Scale (VAS) Score at Specified Timepoints Baseline (Cycle 1) and Cycles 3, 6, 9, 12, 15, 18, 21, 24, 30, 36, 42, 48, 54, and 60 (1 cycle is 28 days) of treatment, once every 6 months during the first 2 years of post-treatment follow-up and annually for 3 years thereafter (up to 10 years) Mean Global Health Status/Quality of Life (QoL) Scale Score at Specified Timepoints, Assessed Using the EORTC QLQ-C30 Baseline (Cycle 1) and Cycles 3, 6, 9, 12, 15, 18, 21, 24, 30, 36, 42, 48, 54, and 60 (1 cycle is 28 days) of treatment, once every 6 months during the first 2 years of post-treatment follow-up and annually for 3 years thereafter (up to 10 years) Substudy: Incidence and Severity of Adverse Events with Giredestrant in Combination with Abemaciclib, with Severity Determined According to NCI-CTCAE v5.0 From first dose of study treatment until 28 days after the last dose of treatment with the combination of giredestrant and abemaciclib or until the end of Year 2, whichever occurs first (up to 2 years)
Trial Locations
- Locations (701)
Hospital Alemán
🇦🇷Recoleta, Argentina
Instituto Medico de la Fundacion Estudios Clinicos
🇦🇷Rosario, Argentina
Centre Hospitalier Chrétien MontLégia
🇧🇪Liège, Belgium
CHR de la Citadelle, Pharmacie
🇧🇪Liège, Belgium
Clinique Sainte-Elisabeth
🇧🇪Namur, Belgium
Cliniques Universitaires UCL de Mont-Godinne
🇧🇪Namur, Belgium
Centrum Medyczne Pratia
🇵🇱Poznan, Poland
Sundsvalls sjukhus
🇸🇪Sundsvall, Sweden
Akademiska Sjukhuset
🇸🇪Uppsala, Sweden
Västmanlands sjukhus Västerås
🇸🇪Västerås, Sweden
Columbus NCORP
🇺🇸Columbus, Ohio, United States
Tumorzentrum Aarau
🇨🇭Aarau, Switzerland
Kantonsspital Baden
🇨🇭Baden, Switzerland
Southern Cancer Center
🇺🇸Daphne, Alabama, United States
CBCC Global Research Inc., at Comprehensive Blood and Cancer Center
🇺🇸Bakersfield, California, United States
Arrowhead Regional Medical Center
🇺🇸Colton, California, United States
Cancer and Blood Specialty Clinic
🇺🇸Fountain Valley, California, United States
St Joseph Heritage Healthcare
🇺🇸Fullerton, California, United States
Long Beach Memorial Medical Center
🇺🇸Long Beach, California, United States
UCLA Hematology/Oncology
🇺🇸Los Angeles, California, United States
Keck Medicine of USC ? Newport Beach
🇺🇸Newport Beach, California, United States
The Center for Cancer Prevention and Treatment at St.Joseph Hospital of Orange
🇺🇸Orange, California, United States
Stanford University Medical Center
🇺🇸Palo Alto, California, United States
Kaiser Permanente - Roseville
🇺🇸Roseville, California, United States
Kaiser Permanente - San Diego
🇺🇸San Diego, California, United States
Kaiser Permanente - San Francisco (2238 Geary)
🇺🇸San Francisco, California, United States
Stanford Cancer Center South Bay
🇺🇸San Jose, California, United States
Sansum Clinic
🇺🇸Santa Barbara, California, United States
Kaiser Permanente - Santa Clara
🇺🇸Santa Clara, California, United States
Torrance Memorial Physician Network/Cancer Care
🇺🇸Torrance, California, United States
Kaiser Permanente - Vallejo
🇺🇸Vallejo, California, United States
Valley Breast Care and Women's Health Center
🇺🇸Van Nuys, California, United States
Rocky Mountain Cancer Centers (Longmont) - USOR
🇺🇸Longmont, Colorado, United States
Stamford Hospital
🇺🇸Stamford, Connecticut, United States
University of Florida
🇺🇸Gainesville, Florida, United States
Memorial Healthcare System - Memorial Regional Hospital
🇺🇸Hollywood, Florida, United States
Baptist - MD Anderson Cancer Center
🇺🇸Jacksonville, Florida, United States
Mount Sinai Comprehensive Cancer Center
🇺🇸Miami Beach, Florida, United States
Miami Cancer Institute of Baptist Health, Inc.
🇺🇸Miami, Florida, United States
Orlando Health Cancer Institute
🇺🇸Orlando, Florida, United States
Miami Cancer Institute-Plantation
🇺🇸Plantation, Florida, United States
Memorial Health University Cancer Center
🇺🇸Savannah, Georgia, United States
University of Illinois at Chicago
🇺🇸Chicago, Illinois, United States
University of Chicago Hospital
🇺🇸Chicago, Illinois, United States
Elmhurst Cancer Center
🇺🇸Elmhurst, Illinois, United States
Joliet Oncology Hematology Associates, Ltd.
🇺🇸Joliet, Illinois, United States
Edward Cancer Center Naperville
🇺🇸Naperville, Illinois, United States
Edward Cancer Center Plainfield
🇺🇸Plainfield, Illinois, United States
Oncology Associates at Mercy Medical Center
🇺🇸Cedar Rapids, Iowa, United States
University of Iowa
🇺🇸Iowa City, Iowa, United States
Cancer Center of Kansas - Kingman
🇺🇸Kingman, Kansas, United States
University of Kentucky
🇺🇸Lexington, Kentucky, United States
Norton Cancer Institute - MDC
🇺🇸Louisville, Kentucky, United States
Hematology/Oncology Clinic, LLP
🇺🇸Baton Rouge, Louisiana, United States
University Medical Center New Orleans
🇺🇸New Orleans, Louisiana, United States
UPMC Western Maryland - Schwab Family Cancer Center
🇺🇸Cumberland, Maryland, United States
University of Maryland
🇺🇸Towson, Maryland, United States
Lahey Clinic Med Ctr
🇺🇸Burlington, Massachusetts, United States
Massachusetts General Hospital
🇺🇸Lexington, Massachusetts, United States
University Of Michigan
🇺🇸Ann Arbor, Michigan, United States
Stefanie Spielman Comprehensive Breast Center
🇺🇸Columbus, Ohio, United States
Metro-Minnesota Community Oncology Research Consortium
🇺🇸Saint Louis Park, Minnesota, United States
University of Missouri-Columbia
🇺🇸Columbia, Missouri, United States
St. Vincent Frontier Cancer Center
🇺🇸Billings, Montana, United States
Nebraska Cancer Specialists
🇺🇸Omaha, Nebraska, United States
University of Nebraska Medical Center
🇺🇸Omaha, Nebraska, United States
Comprehensive Cancer Centers of Nevada
🇺🇸Las Vegas, Nevada, United States
MD Anderson Cancer Center at Cooper
🇺🇸Camden, New Jersey, United States
Hunterdon Hematology Oncology
🇺🇸Flemington, New Jersey, United States
Rutgers Cancer Institute of New Jersey
🇺🇸New Brunswick, New Jersey, United States
Roswell Park Cancer Institute
🇺🇸Buffalo, New York, United States
NYU Winthrop Hospital
🇺🇸Mineola, New York, United States
New York University Cancer Cen
🇺🇸New York, New York, United States
Stony Brook Univ Cancer Ctr
🇺🇸Stony Brook, New York, United States
Messino Cancer Centers
🇺🇸Asheville, North Carolina, United States
Levine Cancer Institute
🇺🇸Charlotte, North Carolina, United States
First Health of the Carolinas
🇺🇸Pinehurst, North Carolina, United States
Rex Cancer Center
🇺🇸Raleigh, North Carolina, United States
UNC Cancer Care at Nash
🇺🇸Rocky Mount, North Carolina, United States
Atrium Health Wake Forest Baptist Medical Center - PPDS
🇺🇸Winston-Salem, North Carolina, United States
Aultman Hospital
🇺🇸Canton, Ohio, United States
Oncology Hematology Care Inc
🇺🇸Cincinnati, Ohio, United States
University Hospitals Cleveland Medical Center
🇺🇸Cleveland, Ohio, United States
Cleveland Clinic
🇺🇸Cleveland, Ohio, United States
SCRI Mark H. Zangmeister Center
🇺🇸Columbus, Ohio, United States
Oncology Associates of Oregon, P.C.
🇺🇸Eugene, Oregon, United States
Kaiser Permanente-Northwest Region
🇺🇸Portland, Oregon, United States
Pinnacle Health
🇺🇸Harrisburg, Pennsylvania, United States
Penn State Univ. Milton S. Hershey Medical Center
🇺🇸Hershey, Pennsylvania, United States
Allegheny Cancer Center
🇺🇸Pittsburgh, Pennsylvania, United States
Magee Womens Hospital
🇺🇸Pittsburgh, Pennsylvania, United States
Reading Hospital
🇺🇸West Reading, Pennsylvania, United States
UPMC Williamsport, Divine Providence Campus
🇺🇸Williamsport, Pennsylvania, United States
Women & Infants Hospital
🇺🇸Providence, Rhode Island, United States
Avera Cancer Institute
🇺🇸Sioux Falls, South Dakota, United States
West Cancer Center & Research Institute
🇺🇸Germantown, Tennessee, United States
Sarah Cannon Research Institute / Tennessee Oncology
🇺🇸Nashville, Tennessee, United States
Texas Oncology, P.A. - El Paso
🇺🇸El Paso, Texas, United States
Texas Oncology (Flower Mound) - USOR
🇺🇸Flower Mound, Texas, United States
Texas Oncology-Fort Worth Cancer Center
🇺🇸Fort Worth, Texas, United States
Baylor College of Medicine Medical Center
🇺🇸Houston, Texas, United States
Houston Methodist Cancer Center
🇺🇸Houston, Texas, United States
Joe Arrington Cancer Research & Treatment Center
🇺🇸Lubbock, Texas, United States
Texas Oncology (McAllen) - USOR
🇺🇸McAllen, Texas, United States
Texas Oncology McKinney
🇺🇸McKinney, Texas, United States
USOR - Texas Oncology - San Antonio Northeast
🇺🇸San Antonio, Texas, United States
US Oncology Research, Inc.
🇺🇸The Woodlands, Texas, United States
Texas Oncology (Tyler) - USOR
🇺🇸Tyler, Texas, United States
Texas Oncology (Waco) - USOR
🇺🇸Waco, Texas, United States
Centra Alan B. Pearson Regional Cancer Center
🇺🇸Lynchburg, Virginia, United States
Bon Secours Mercy Health
🇺🇸Midlothian, Virginia, United States
Virginia Oncology Associates
🇺🇸Norfolk, Virginia, United States
Virginia Commonwealth University - Massey Cancer Center
🇺🇸Richmond, Virginia, United States
Oncology and Hematology Associates of Southwest Virginia, Inc.,-Blacksburg
🇺🇸Roanoke, Virginia, United States
Swedish Cancer Institute
🇺🇸Seattle, Washington, United States
West Virginia University Hospitals Inc
🇺🇸Morgantown, West Virginia, United States
University of Wisconsin
🇺🇸Madison, Wisconsin, United States
Froedtert and The Medical College of Wisconsin
🇺🇸Milwaukee, Wisconsin, United States
Hospital Italiano Regional del Sur
🇦🇷Bahia Blanca, Argentina
Fundacion Intectus
🇦🇷Bariloche, Argentina
Instituto de Investigaciones Clinicas-Mar del Plata
🇦🇷Buenos Aires, Argentina
Instituto de Investigaciones Metabólicas (IDIM)
🇦🇷Buenos Aires, Argentina
Fundación CENIT para la Investigación en Neurociencias
🇦🇷Buenos Aires, Argentina
Centro Oncologico Korben
🇦🇷Caba, Argentina
Fundacion Medica de Rio Negro Y Nuequen
🇦🇷Cipoletti, Argentina
Consultorios Médicos Dr. Doreski
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
Sanatorio Allende Servicio Nefrología
🇦🇷Córdoba, Argentina
Centro Medico Privado CEMAIC
🇦🇷Córdoba, Argentina
Fundación Ars Medica
🇦🇷Jujuy, Argentina
Centro Oncologico Riojano Integral (CORI)
🇦🇷La Rioja, Argentina
Centro de Investigaciones Medicas Mar Del Plata
🇦🇷Mar Del Plata, Argentina
Hospital Privado de La Comunidad
🇦🇷Mar Del Plata, Argentina
Centro de Investigacion Pergamino SA
🇦🇷Pergamino, Argentina
Instituto de Especialidades de la Salud Rosario - Clínica del Tórax
🇦🇷Rosario, Argentina
Sanatorio Parque de Rosario
🇦🇷Rosario, Argentina
Instituto de Oncologia de Rosario
🇦🇷Rosario, Argentina
Centro Polivalente de Asistencia e Investigacion Clinica - CER San Juan
🇦🇷San Juan, Argentina
Centro Médico Privado de Reumatología
🇦🇷San Miguel de Tucuman, Argentina
Centro Medico San Roque
🇦🇷San Miguel de Tucuman, Argentina
Organizacion Medica de Investigacion
🇦🇷San Nicolás, Argentina
Centro de Investigación Clínica ? Clínica Viedma
🇦🇷Viedma, Argentina
Border Medical Oncology Research Unit
🇦🇺Albury, New South Wales, Australia
Bankstown-Lidcombe Hospital
🇦🇺Bankstown, New South Wales, Australia
Campbelltown Hospital
🇦🇺Campbelltown, New South Wales, Australia
Liverpool Hospital
🇦🇺Liverpool, New South Wales, Australia
Westmead Hospital
🇦🇺Northmead, New South Wales, Australia
North Coast Cancer Institute - Port Macquarie
🇦🇺Port Macquarie, New South Wales, Australia
Mater Hospital
🇦🇺Wollstonecraft, New South Wales, Australia
Wesley Medical Centre
🇦🇺Auchenflower, Queensland, Australia
Mater Cancer Care Centre
🇦🇺Brisbane, Queensland, Australia
Cairns Hospital
🇦🇺Cairns, Queensland, Australia
Townsville Hospital
🇦🇺Townsville, Queensland, Australia
Princess Alexandra Hospital
🇦🇺Woolloongabba, Queensland, Australia
Royal Adelaide Hospital
🇦🇺Adelaide, South Australia, Australia
St Andrews Medical Centre
🇦🇺Adelaide, South Australia, Australia
Flinders Medical Centre
🇦🇺Bedford Park, South Australia, Australia
Ashford Cancer Centre Research
🇦🇺Kurralta Park, South Australia, Australia
ICON Cancer Care Hobart
🇦🇺Hobart, Tasmania, Australia
Bendigo Hospital
🇦🇺Bendigo, Victoria, Australia
Northern Hospital
🇦🇺Epping, Victoria, Australia
Frankston Hospital
🇦🇺Frankston, Victoria, Australia
Maroondah Hospital
🇦🇺Ringwood East, Victoria, Australia
Goulburn Valley Health
🇦🇺Shepparton, Victoria, Australia
Sunshine Hospital
🇦🇺St Albans, Victoria, Australia
South West Healthcare
🇦🇺Warrnambool, Victoria, Australia
Ballarat Oncology & Haematology
🇦🇺Wendouree, Victoria, Australia
Sir Charles Gairdner Hospital
🇦🇺Nedlands, Western Australia, Australia
LKH-Universitätsklinikum Klinikum Graz
🇦🇹Graz, Austria
Medizinische Universitat Innsbruck
🇦🇹Innsbruck, Austria
Ordensklinikum Linz GmbH
🇦🇹Linz, Austria
LKH Rankweil, Interne E
🇦🇹Rankweil, Austria
Universitätsklinikum Salzburg
🇦🇹Salzburg, Austria
Universitätsklinikum St. Pölten
🇦🇹St. Pölten, Austria
A.ö. Krankenhaus der Barmherzigen Brüder
🇦🇹St. Veit, Austria
Oö. Gesundheits- und Spitals-AG/LKH Steyr
🇦🇹Steyr, Austria
Klinikum Wels-Grieskirchen GmbH
🇦🇹Wels, Austria
Medizinische Universitat Wien Medical University of Vienna
🇦🇹Wien, Austria
Institute Jules Bordet
🇧🇪Belgium, Belgium
Grand Hopital de Charleroi asbl
🇧🇪Charleroi, Belgium
UZ Leuven
🇧🇪Leuven, Belgium
CH de l'Ardenne (Libramont)
🇧🇪Libramont, Belgium
Chu Sart Tilman
🇧🇪Liege, Belgium
GZA Ziekenhuizen Antwerpen campus Sint-Augustinus
🇧🇪Wilrijk, Belgium
Clinical Center Banja Luka
🇧🇦Banja Luka, Bosnia and Herzegovina
Clinical Hospital Mostar
🇧🇦Mostar, Bosnia and Herzegovina
Clinical Center University of Sarajevo
🇧🇦Sarajevo, Bosnia and Herzegovina
University Clinical Center Tuzla
🇧🇦Tuzla, Bosnia and Herzegovina
Nucleo de Oncologia da Bahia - NOB
🇧🇷Salvador, Bahia, Bahia, Brazil
Centro de Oncologia da Bahia
🇧🇷Salvador/BA, Bahia, Brazil
Centro Odonito Medico Linus Pauling - Clinica de O
🇧🇷Salvador, Bahia, Brazil
Terapia de Inovação Clínica Assistência Multidiciplinar Em Oncologia Ética
🇧🇷Salvador, Bahia, Brazil
Centro de Pesquisas Clinicas em Oncologia - CPCO
🇧🇷Cachoeiro de Itapemirim, Espírito Santo, Brazil
Hospital Araujo Jorge
🇧🇷Goiania, Goiás, Brazil
Cenantron - Centro Avancado de Tratamento Oncologico
🇧🇷Belo Horizonte, Minas Gerais, Brazil
Oncoclinicas do Brasil Servicos Medicos As
🇧🇷Belo Horizonte, Minas Gerais, Brazil
Hospital de Clinicas de Porto Alegre HCPA PPDS
🇧🇷Porto Alegre, Pará, Brazil
Hospital do Cancer de Pernambuco - HCP
🇧🇷Recife, Pernambuco, Brazil
Universidade de Caxias do Sul - Rio Grande do Sul
🇧🇷Caixas Do Sul, Rio Grande Do Sul, Brazil
ONCOSITE Centro de Pesquisa Clínica Em Oncologia
🇧🇷Ijui, Rio Grande Do Sul, Brazil
Hospital Bruno Born
🇧🇷Lajeado, Rio Grande Do Sul, Brazil
Hospital São Vicente de Paulo X
🇧🇷Passo Fundo, Rio Grande Do Sul, Brazil
Hospital Moinhos de Vento
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Irmandade Da Santa Casa de Misericordia de Porto Alegre
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Hospital Mae de Deus
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Hospital Sao Lucas - PUCRS
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Hospital Nossa Senhora da Conceição
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Clinica de Neoplasias Litoral
🇧🇷Itajai, Santa Catarina, Brazil
*X*Fundação Pio XII Hospital de Câncer de Barretos
🇧🇷Barretos, São Paulo, Brazil
Hospital Amaral Carvalho
🇧🇷Jau, São Paulo, Brazil
Instituto de Oncologia Clínica de Piracicaba
🇧🇷Piracicaba, São Paulo, Brazil
Faculdade de Medicina do ABC - FMABC
🇧🇷Santo Andre, São Paulo, Brazil
Fundação Faculdade Regional de Medicina de São José do Rio Preto
🇧🇷Sao Jose Do Rio Preto, São Paulo, Brazil
Instituto do Cancer do Estado de Sao Paulo - ICESP
🇧🇷Sao Paulo, São Paulo, Brazil
Instituto de Oncologia de Sorocaba - CEPOS
🇧🇷Sorocaba, São Paulo, Brazil
Instituto Nacional de Cancer - INCa
🇧🇷Rio de Janeiro, Brazil
Instituto Brasileiro De Controle Do Câncer - IBCC
🇧🇷São Paulo, Brazil
Clinica de Pesquisas e Centro de Estudos Oncologia Ginecologica e Mamaria Ltda
🇧🇷São Paulo, Brazil
Onco Star Sp Oncologia Ltda
🇧🇷São Paulo, Brazil
Complex Oncology Center Burgas
🇧🇬Burgas, Bulgaria
Multiprofile Hospital for Active Treatment Uni Hospital
🇧🇬Panagyurishte, Bulgaria
Arthur J.E. Child Comprehensive Cancer Center-Calgary
🇨🇦Calgary, Alberta, Canada
Cross Cancer Institute
🇨🇦Edmonton, Alberta, Canada
British Columbia Cancer Agency
🇨🇦Vancouver, British Columbia, Canada
The Moncton Hospital
🇨🇦Moncton, New Brunswick, Canada
Sault Area Hospital
🇨🇦Sault Ste. Marie, Ontario, Canada
Centre Integre Universitaire de Sante et de Services Sociaux du Saguenay Lac Saint Jean
🇨🇦Chicoutimi, Quebec, Canada
Hopital Charles Le Moyne
🇨🇦Greenfield Park, Quebec, Canada
CIUSSS-de-l?Est-de-l?Île-de-Montréal
🇨🇦Montreal, Quebec, Canada
CHUM
🇨🇦Montreal, Quebec, Canada
Sir Mortimer B Davis Jewish General Hospital
🇨🇦Montreal, Quebec, Canada
McGill University Health Center
🇨🇦Montreal, Quebec, Canada
St-Jérome Medical Research, Inc.
🇨🇦Saint-Jerome, Quebec, Canada
Centre Hospitalier Universitaire de Sherbrooke
🇨🇦Sherbrooke, Quebec, Canada
Allan Blair Cancer Centre
🇨🇦Regina, Saskatchewan, Canada
CHU de Quebec-Universite Laval
🇨🇦Quebec, Canada
IC La Serena Research SpA
🇨🇱La Serena, Chile
BIOCINETIC SpA
🇨🇱Peñalolen, Chile
Centro de Estudios Clínicos SAGA SpA
🇨🇱Providencia, Chile
Fundacion Arturo Lopez Perez
🇨🇱Providencia, Chile
Oncovida - Santiago
🇨🇱Providencia, Chile
Patagonia Research
🇨🇱Puerto Montt, Chile
Servicios Médicos URUMED SpA
🇨🇱Rancagua, Chile
Meditek Ltda
🇨🇱Santiago, Chile
Icegclinic
🇨🇱Santiago, Chile
Medwal
🇨🇱Santiago, Chile
Clinica Universidad Catolica del Maule
🇨🇱Talca, Chile
James Lind Centro de Investigación Del Cáncer
🇨🇱Temuco, Chile
Oncocentro Apys
🇨🇱Vina Del Mar, Chile
Centro de Investigaciones Clinicas Viña del Mar
🇨🇱Viña del Mar, Chile
Henan Cancer Hospital
🇨🇳Zhengzhou, Henan, China
Hunan Cancer Hospital
🇨🇳Changsha, Hunan, China
Jiangxi Cancer Hospital
🇨🇳Nanchang, Jiangxi, China
The First Hospital of Jilin University
🇨🇳Changchun, Jilin, China
West China Hospital, Sichuan University
🇨🇳Chengdu, Sichuan, China
First Affiliated Hospital of Medical College of Xi'an Jiaotong University
🇨🇳Xi'an, China
Peking University People's Hospital
🇨🇳Beijing, China
Jilin Cancer Hospital
🇨🇳Changchun, China
The Second Affiliated Hospital of Dalian Medical University
🇨🇳Dalian, China
Fujian Provincial Cancer Hospital
🇨🇳Fuzhou City, China
Guangdong Provincial Maternity and Child Care Cent
🇨🇳Guangzhou, China
Sun yat-sen University Cancer Center
🇨🇳Guangzhou, China
The Second Affiliated Hospital of Zhejiang University School of Medicine
🇨🇳Hangzhou City, China
Sir Run Run Shaw Hospital Zhejiang University
🇨🇳Hangzhou City, China
The First Affiliated Hospital of College of Medicine, Zhejiang University
🇨🇳Hangzhou, China
Zhejiang Cancer Hospital
🇨🇳Hangzhou, China
Harbin Medical University Cancer Hospital
🇨🇳Harbin City, China
Anhui Province Cancer Hospital
🇨🇳Hefei, China
Jinan Central Hospital
🇨🇳Jinan City, China
Yunnan Cancer Hospital
🇨🇳Kunming, China
Linyishi Cancer Hospital
🇨🇳Linyi, China
The Third Hospital of Nanchang
🇨🇳Nanchang City, China
Guangxi Cancer Hospital of Guangxi Medical University
🇨🇳Nanning, China
The Second People's Hospital of Neijiang
🇨🇳Neijiang, China
Fudan University Shanghai Cancer Center
🇨🇳Shanghai City, China
Shengjing Hospital of China Medical University
🇨🇳ShenYang, China
The Fourth Hospital of Hebei Medical University
🇨🇳Shijiazhuang, China
Tianjin Medical University Cancer Institute & Hospital
🇨🇳Tianjin City, China
Wenzhou Medical College - The First Affiliated Hospital GCP
🇨🇳Wenzhou City, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology
🇨🇳Wuhan City, China
Tongji Hospital Tongji Medical College Huazhong University of Science and Technology
🇨🇳Wuhan City, China
Hubei Cancer Hospital
🇨🇳Wuhan, China
Air Force Military Medical University Xijing Hospital
🇨🇳Xi'an City, China
The First Affiliated Hospital of Xiamen University
🇨🇳Xiamen, China
The Affiliated Hospital of Xuzhou Medical University
🇨🇳Xuzhou, China
Hemato Oncólogos S.A
🇨🇴Cali, Colombia
FOSCAL
🇨🇴Floridablanca, Colombia
Oncomedica S.A.
🇨🇴Montería, Colombia
Oncólogos Del Occidente SA
🇨🇴Pereira, Colombia
Sociedad de Oncología y hematología del Cesar Ltda
🇨🇴Valledupar, Colombia
Consultorio Oncologico-Hospital Metropolitano Linc
🇨🇷Moravia, Costa Rica
Instituto de Investigación en Ciencias Médicas S.A.
🇨🇷San Jose, Costa Rica
Oncotech S.A.
🇨🇷San José, Costa Rica
Metropolitano Research Institute Lindora
🇨🇷San José, Costa Rica
Centro de Cáncer y Hematología
🇨🇷San José, Costa Rica
Clinical Hospital Centre Osijek
🇭🇷Osijek, Croatia
General Hospital Pula
🇭🇷Pula, Croatia
University Hospital of Split
🇭🇷Split, Croatia
General Hospital Varazdin
🇭🇷Varazdin, Croatia
Clinical Hospital Sestre Milosrdnice
🇭🇷Zagreb, Croatia
Klinicki bolnicki centar Zagreb
🇭🇷Zagreb, Croatia
Fakultni nemocnice Olomouc
🇨🇿Ostrava - Poruba, Czechia
Vseobecna fakultni nemocnice v Praze
🇨🇿Praha 2, Czechia
Fakultni nemocnice v Motole
🇨🇿Praha 5, Czechia
Fakultni nemocnice Kralovske Vinohrady
🇨🇿Praha, Czechia
Fakultni Thomayerova Nemocnice
🇨🇿Praha, Czechia
Alexandria Uni
🇪🇬Alexandria, Egypt
Medical Technology Center for Research and Services
🇪🇬Alexandria, Egypt
Kasr Al Ainy School of Medicine-Cairo University
🇪🇬Cairo, Egypt
Ain Shams University Hospital
🇪🇬Cairo, Egypt
Mansoura University Hospital
🇪🇬El Mansura, Egypt
Sohag Oncology Center
🇪🇬Markaz Sohag, Egypt
Dar ElSalam Cancer City
🇪🇬Old Cairo, Egypt
Helsingin yliopistollinen keskussairaala
🇫🇮Helsinki, Finland
Tampereen yliopistollinen sairaala
🇫🇮Tampere, Finland
Turun Yliopistollinen Keskussairaala
🇫🇮Turku, Finland
Centre Francois Baclesse
🇫🇷Caen, Calvados, France
Sas Clinique De L Europe - Amiens
🇫🇷Amiens, France
Hopital d'Argenteuil
🇫🇷Argenteuil, France
Centre Hospitalier Regional Universitaire de Brest - Hopital de la Cavale Blanche
🇫🇷Brest, France
Institut Daniel Hollard
🇫🇷Grenoble, France
Centre Hospitalier Departemental de Vendee
🇫🇷La Roche Sur Yon, France
Centre de cancérologie de la Sarthe - Aile B
🇫🇷Le Mans, France
Centre Oscar Lambret
🇫🇷Lille, France
CHU Dupuytren
🇫🇷Limoges, France
Hôpital Privé Clairval
🇫🇷Marseille, France
Clinique Clémentville
🇫🇷Montpellier, France
Clinique Catherine de Sienne
🇫🇷Nantes, France
Institut Curie
🇫🇷Paris, France
Hopital Universitaire Pitie Salpetriere
🇫🇷Paris, France
Hopital Tenon
🇫🇷Paris, France
Hopital Saint Louis
🇫🇷Paris, France
Hôpital Européen Georges Pompidou
🇫🇷Paris, France
Hopital privé des Côtes Armor
🇫🇷Plérin, France
EDOG - Centre Eugene Marquis Centre Regional de Lutte Contre Le Cancer - PPDS
🇫🇷Rennes Cedex, France
Centre Henri Becquerel
🇫🇷Rouen, France
Curie Saint Cloud
🇫🇷St Cloud, France
Institut de Cancérologie Strasbourg Europe
🇫🇷Strasbourg, France
Institut Gustave Roussy
🇫🇷Villejuif, France
High Technology Hospital MedCenter Ltd
🇬🇪Batumi, Georgia
Acad. F. Todua Medical Center
🇬🇪Tbilisi, Georgia
Ltd Israel-Georgia Medical Research Clinic Helsicore
🇬🇪Tbilisi, Georgia
LTD Health House
🇬🇪Tbilisi, Georgia
Institute of Clinical Oncology LTD
🇬🇪Tbilisi, Georgia
Tbilisi Oncology Dispensary
🇬🇪Tbilisi, Georgia
LTD TIM, Tbilisi Institute of Medicine
🇬🇪Tbilisi, Georgia
Multiprofile Clinic Consilium Medulla
🇬🇪Tbilisi, Georgia
S Khechinashvili University Clinic Ltd
🇬🇪Tbilisi, Georgia
Hämatologisch/onkologische Gemeinschaftspraxis
🇩🇪Augsburg, Germany
Ambulantes Tumorzentrum Spandau
🇩🇪Berlin, Germany
Lübecker Onkologische Schwerpunktpraxis
🇩🇪Bonn, Germany
Marienhospital Bottrop
🇩🇪Bottrop, Germany
Klinikum Chemnitz gGmbH
🇩🇪Chemnitz, Germany
Universitatsklinikum Erlangen
🇩🇪Erlangen, Germany
KEM/Evang. Kliniken Essen Mitte gGmbH
🇩🇪Essen, Germany
Franziskus-Hospital Harderberg
🇩🇪Georgsmarienhutte, Germany
SRH Wald-Klinikum Gera
🇩🇪Gera, Germany
Mammazentrum Hamburg am Krankenhaus Jerusalem
🇩🇪Hamburg, Germany
Gynäkologisch Onkologische Praxis Hannover
🇩🇪Hannover, Germany
Vincentius-Diakonissen-Kliniken gAG
🇩🇪Karlsruhe, Germany
Facharztpraxis für Gynäkologie und Geburtshilfe PD Dr. med. Christian Kurbacher
🇩🇪Lübeck, Germany
Universitätsmedizin Mainz
🇩🇪Mainz, Germany
Klinikum Mannheim GmbH Universitätsklinikum
🇩🇪Mannheim, Germany
Praxis fuer gynaekologische onkologie Prof. Dr. me
🇩🇪Mönchengladbach, Germany
Hämatologie und Onkologie Ravensburg / Wangen
🇩🇪Ravensburg, Germany
Leopoldina Krankenhaus Schweinfurt
🇩🇪Schweinfurt, Germany
Praxis fur Haematologie und Internistische Onkologie
🇩🇪Velbert, Germany
Henry Dunant Hospital
🇬🇷Athens, Greece
University of Athens, Hematological Clinic,
🇬🇷Athens, Greece
Sotiria Chest Hospital of Athens
🇬🇷Athens, Greece
General Oncology Hospital Kifissias "Oi Agioi Anargyroi"
🇬🇷Athens, Greece
Aretaieio Hospital of Athens
🇬🇷Athina, Greece
Attikon University General Hospital
🇬🇷Chaidari, Greece
Metropolitan General Hospital
🇬🇷Cholargos, Greece
Metropolitan Hospital First Oncology Clinic
🇬🇷Faliro, Greece
Metropolitan Hospital Fourth Oncology Clinic
🇬🇷Faliro, Greece
University General Hospital of Heraklion
🇬🇷Herakleion, Greece
University General Hospital of Ioannina
🇬🇷Ioannina, Greece
University General Hospital of Larissa
🇬🇷Larissa, Greece
IASO Obstetrics Gynecology Clinic
🇬🇷Marousi, Greece
Medical Center of Athens
🇬🇷Marousi, Greece
Agios Loucas Clinic SA
🇬🇷Panorama, Greece
Olympion Clinic
🇬🇷Patras, Greece
University General Hospital of Patras
🇬🇷Patras, Greece
Bioclinic Thessaloniki
🇬🇷Thessaloniki, Greece
Interbalkan Medical Center of Thessaloniki
🇬🇷Thessaloniki, Greece
Euromedica PPDS
🇬🇷Thessaloniki, Greece
Papageorgiou General Hospital of Thessaloniki
🇬🇷Thessaloniki, Greece
Celan S.A.
🇬🇹Ciudad de Guatemala, Guatemala
INTEGRA Cancer Institute
🇬🇹Ciudad de Guatemala, Guatemala
Grupo Medico Angeles
🇬🇹Ciudad de Guatemala, Guatemala
Oncomedica
🇬🇹Guatemala, Guatemala
Clínica Médica Especializada en Hematología
🇬🇹Guatemala, Guatemala
Centro Medico Integral de Cancerologia CEMIC
🇬🇹Salcajá, Guatemala
Pamela Youde Nethersole Eastern Hospital
🇭🇰Chai Wan, Hong Kong
Queen Mary Hospital
🇭🇰Hong Kong, Hong Kong
Tuen Mun Hospital
🇭🇰Hong Kong, Hong Kong
Semmelweis Egyetem
🇭🇺Budapest, Hungary
Tolna Megyei Balassa János Kórház
🇭🇺Budapest, Hungary
Budapesti Uzsoki Utcai Kórház
🇭🇺Budapest, Hungary
Debreceni Egyetem Klinikai Kozpont
🇭🇺Debrecen, Hungary
Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz
🇭🇺Miskolc, Hungary
Szent Borbala Korhaz
🇭🇺Tatabánya, Hungary
Zala Megyei Szent Rafael Korhaz
🇭🇺Zalaegersteg, Hungary
HCG City Cancer Centre
🇮🇳Vijayawada, Andhra Pradesh, India
State Cancer Institute, Indira Gandhi Institute of Medical Sciences (IGIMS)
🇮🇳Patna, Bihar, India
Gujarat Cancer & Research Inst.
🇮🇳Ahmadabad CITY, Gujarat, India
Nirmal Hospital
🇮🇳Surat, Gujarat, India
Kiran Hospital Multi Super Speciality Hospital and Research Center
🇮🇳Surat, Gujarat, India
Himalaya Cancer Hospital & Research Institute
🇮🇳Vadodara, Gujarat, India
Kailash Cancer Hospital and Research Center
🇮🇳Vadodara, Gujarat, India
KLES Dr Prabhakar Kore Hospital and Medical Research Centre
🇮🇳Belagavi, Karnataka, India
Sujan Surgical Cancer Hospital And Amravati Cancer Foundation
🇮🇳Amravati, Maharashtra, India
Kolhapur Cancer Centre
🇮🇳Kolhapur, Maharashtra, India
Tata Memorial Hospital
🇮🇳Mumbai, Maharashtra, India
Government Medical College
🇮🇳Nagpur, Maharashtra, India
HCG NCHRI Cancer Center
🇮🇳Nagpur, Maharashtra, India
Shalinitai Meghe Medical College and Hospital
🇮🇳Nagpur, Maharashtra, India
HCG Manavata Cancer Centre
🇮🇳Nashik, Maharashtra, India
Chopda Medicare & Research Centre pvt. Ltd
🇮🇳Nashik, Maharashtra, India
Apex Wellness Hospital
🇮🇳Nashik, Maharashtra, India
Sahyadri Speciality Hospital
🇮🇳Pune City, Maharashtra, India
Sahyadri Super Specialty Hospital Hadapsar
🇮🇳Pune, Maharashtra, India
Lokmanya Holistic Cancer Care and Research Center (LMRC)
🇮🇳Pune, Maharashtra, India
All India Institute of Medical Sciences, Bhubaneswar
🇮🇳Bhubaneswar, Odisha, India
Erode Cancer Centre
🇮🇳Erode, Tamil NADU, India
Christian Medical College-Ranipet Campus
🇮🇳Ratnagiri Kilminnal, Tamil NADU, India
King George Medical University (KGMU)
🇮🇳Lucknow, Uttar Pradesh, India
Institute of Post Graduate Medical Education and Research (IPGMER) and SSKM Hospital
🇮🇳Kolkata, WEST Bengal, India
Health Point Hospital - Kolkata
🇮🇳Kolkata, WEST Bengal, India
Cork University Hospital
🇮🇪Cork, Ireland
Bon Secours Hospital
🇮🇪Cork, Ireland
St Vincents University Hospital
🇮🇪Dublin, Ireland
Beaumont Hospital
🇮🇪Dublin, Ireland
Galway University Hospital
🇮🇪Galway, Ireland
Mid- Western Regional Hospital Limerick
🇮🇪Limerick, Ireland
Waterford Regional Hospital
🇮🇪Waterford, Ireland
Shamir Medical Center Assaf Harofeh
🇮🇱Beer Jacob, Israel
Soroka University Medical Centre
🇮🇱Beer Sheba, Israel
Sheba Medical Center - PPDS
🇮🇱Ramat Gan, Israel
Tel-Aviv Sourasky Medical Center
🇮🇱Tel Aviv, Israel
Azienda Ospedaliera Universitaria Senese
🇮🇹Siena, Abruzzo, Italy
Azienda Ospedaliera di Rilievo Nazionale e di Alta Specialita San Giuseppe Moscati
🇮🇹Avellino, Campania, Italy
Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione G. Pascale
🇮🇹Napoli, Campania, Italy
Azienda Ospedaliero Universitaria di BolognaPoliclinico S.Orsola-Malpighi
🇮🇹Bologna, Emilia-Romagna, Italy
International Cancer Institute (ICI)
🇰🇪Eldoret, Kenya
Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori IRST - PPDS
🇮🇹Meldola, Emilia-Romagna, Italy
Arcispedale Santa Maria Nuova
🇮🇹Reggio Emilia, Emilia-Romagna, Italy
Fondazione Policlinico Universitario A Gemelli
🇮🇹Roma, Emilia-Romagna, Italy
Ospedale San Raffaele S.r.l. - PPDS
🇮🇹Milano, Lombardia, Italy
Istituto Nazionale Tumori Regina Elena
🇮🇹Milano, Lombardia, Italy
ASST Grande Ospedale Metropolitano Niguarda - Presidio Ospedaliero Ospedale Niguarda Ca' Granda
🇮🇹Milano, Lombardia, Italy
Istituto Clinico Humanitas
🇮🇹Rozzano (MI), Lombardia, Italy
Ospedale San Giuseppe
🇮🇹Empoli, Toscana, Italy
Azienda Ospedaliera Universitaria Careggi
🇮🇹Firenze, Toscana, Italy
Ospedale Civile - Livorno
🇮🇹Livorno, Toscana, Italy
Azienda Ospedaliero Universitaria Pisana
🇮🇹Pisa, Toscana, Italy
IRCCS Ospedale Sacro Cuore Don Calabria
🇮🇹Negrar, Veneto, Italy
Fukushima Medical University Hospital
🇯🇵Fukushima, Japan
Hiroshima University Hospital
🇯🇵Hiroshima, Japan
Social Medical Corporation Hakuaikai Sagara Hospital
🇯🇵Kagoshima, Japan
Tokai University Hospital
🇯🇵Kanagawa, Japan
Saitama Cancer Center
🇯🇵Kitaadachi-gun, Japan
Kumamoto University Hospital
🇯🇵Kumamoto-Shi Chuo-Ku, Japan
Nahanishi Clinic
🇯🇵Naha-shi, Japan
National Hospital Organization Osaka National Hospital
🇯🇵Osaka, Japan
Osaka International Cancer Institute
🇯🇵Osaka, Japan
National Hospital Organization Hokkaido Cancer Center
🇯🇵Sapporo-shi, Japan
St. Luke's International Hospital
🇯🇵Tokyo, Japan
The Cancer Institute Hospital of Japanese Foundation For Cancer Research
🇯🇵Tokyo, Japan
Aga Khan University Hospital
🇰🇪Nairobi, Kenya
Chungbuk National University Hospital
🇰🇷Cheongju-si, Korea, Republic of
Soon Chun Hyang University Cheonan Hospital
🇰🇷Dongnam-gu, Cheonan-si, Korea, Republic of
Yonsei University Wonju Severance Christian Hospital
🇰🇷Gangwon-do, Korea, Republic of
National Cancer Centre
🇰🇷Gyeonggi-do, Korea, Republic of
CHA Bundang Medical Center
🇰🇷Gyeonggi-do, Korea, Republic of
Inha University Hospital
🇰🇷Incheon, Korea, Republic of
Gachon University Gil Medical Center
🇰🇷Namdong-Gu, Korea, Republic of
Korea University Anam Hospital
🇰🇷Seongbuk-Gu, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Asan Medical Center - PPDS
🇰🇷Seoul, Korea, Republic of
Gangnam Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
Korea University Guro Hospital
🇰🇷Seoul, Korea, Republic of
Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
The Catholic University of Korea Seoul St. Mary?s Hospital
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center - PPDS
🇰🇷Seoul, Korea, Republic of
Ulsan University Hosiptal
🇰🇷Songpa-Gu, Korea, Republic of
Ajou University Hospital
🇰🇷Suwon City, Korea, Republic of
Pauls Stradins Clinical University Hospital
🇱🇻R?ga, Latvia
Hospital Kuala Lumpur
🇲🇾Kuala Lumpur, FED. Territory OF Kuala Lumpur, Malaysia
University Malaya Medical Centre
🇲🇾Kuala Lumpur, FED. Territory OF Kuala Lumpur, Malaysia
National Cancer Institute IKN
🇲🇾Putrajaya, Federal Territory OF Putrajaya, Malaysia
Pantai Hospital Sungai Petani
🇲🇾Sungai Petani, Kedah, Malaysia
Sarawak General Hospital
🇲🇾Buzia?, Sarawak, Malaysia
Beacon International Specialist Centre
🇲🇾Petaling Jaya, Selangor, Selangor, Malaysia
Hospital Pulau Pinang
🇲🇾Penang, Malaysia
Centro de Investigación en Artritis y Osteoporosis - PPDS
🇲🇽Mexicali, BAJA California, Mexico
Office of Alma Magdalena Astorga-Ramos, MD
🇲🇽Gómez Palacio, Durango, Mexico
Dr. José Luis González Trujillo
🇲🇽León de Los Aldama, Guanajuato, Mexico
Hospital Civil Fray Antonio Alcalde
🇲🇽Guadalajara, Jalisco, Mexico
Health Pharma Professional Research
🇲🇽Cdmx, Mexico CITY (federal District), Mexico
Clínica Integral Internacional de Oncología S de RL de CV
🇲🇽Puebla, Mexico CITY (federal District), Mexico
Accelerium S. de R.L. de C.V.
🇲🇽Monterrey, Nuevo LEON, Mexico
Hospital Universitario Dr. Jose Eleuterio Gonzalez
🇲🇽Monterrey, Nuevo LEON, Mexico
Centro de Investigacion Clinica de Oaxaca
🇲🇽Oaxaca de Juárez, Oaxaca, Mexico
Unidad Médica Onco-Hematológica
🇲🇽Heroica Puebla de Zaragoza, Puebla, Mexico
Investigación Médica de Alta Especialidad
🇲🇽Querétaro, Queretaro, Mexico
Neurociencias Estudios Clinicos S.C.
🇲🇽Culiacán, Sinaloa, Mexico
Merida | Investigacion Clinica
🇲🇽Mérida, Yucatan, Mexico
Centro de Investigacion Medica Aguascalientes
🇲🇽Aguascalientes, Mexico
Centro Oncologico Alianza XXI
🇲🇽Mexico, Mexico
Oaxaca Site Management Organization
🇲🇽Oaxaca, Mexico
Oncológico Potosino
🇲🇽San Luis Potosí, Mexico
Centro Hemato-Oncologico Privado CHOP
🇲🇽Toluca, Mexico
Hagaziekenhuis
🇳🇱'S-Gravenhage, Netherlands
Catharina Hospital
🇳🇱Eindhoven, Netherlands
Viecuri Medisch Centrum
🇳🇱Venlo, Netherlands
PHI Clinical Hospital Dr Trifun Panovski Bitola
🇲🇰Bitola, North Macedonia
Acibadem Sistina Hospital
🇲🇰Skopje, North Macedonia
PHI University Clinic of Radiotherapy and Oncology
🇲🇰Skopje, North Macedonia
Hospital Nacional Daniel A Carrion
🇵🇪Bellavista, Peru
Hospital Militar Central
🇵🇪Jesus Maria, Peru
Hospital Central Fuerza Aerea Del Peru
🇵🇪Lima, Peru
Clínica Santa Beatriz
🇵🇪Lima, Peru
Oncologia S.A.C. - Instituto Peruano de Oncología & Radioterapia
🇵🇪Lima, Peru
Oncosalud Sac
🇵🇪Lima, Peru
Clinica Peruana Americana
🇵🇪Trujillo, Peru
University of Santo Tomas Hospital
🇵🇭Manila, National Capital Region, Philippines
Riverside Medical Center, Inc.
🇵🇭Bacolod City, Western Visayas (Region VI), Philippines
Baguio General Hospital and Medical Center
🇵🇭Baguio City, Philippines
Saint Louis University Hospital of Sacred Heart
🇵🇭Baguio City, Philippines
Metro Davao Medical and Research Center
🇵🇭Davao City, Philippines
St. Paul's Hospital
🇵🇭Iloilo City, Philippines
Cardinal Santos Medical Center
🇵🇭Manila, Philippines
The Medical City
🇵🇭Pasig City, Philippines
East Avenue Medical Center
🇵🇭Quezon City, Philippines
St. Luke's Medical Center - Quezon City
🇵🇭Quezon City, Philippines
Centrum Onkologii im. Prof. F. Lukaszczyka w Bydgoszczy
🇵🇱Bydgoszcz, Poland
Szpital Morski Im. Pck
🇵🇱Gdynia, Poland
Narodowy Instytut Onkologii im. M.Sk?odowskiej-Curie - Pa?stwowy Instytut Badawczy Oddzia? Gliwice
🇵🇱Gliwice, Poland
Regionalny Szpital Specjalistyczny im. W. Bieganskiego
🇵🇱Grudziadz, Poland
Narodowy Instytut Onkologii - Panstwowy Instytut Badawczy, Oddzia? w Krakowie
🇵🇱Kraków, Poland
Centrum Terapii Wspolczesnej
🇵🇱Lodz, Poland
Centrum Onkologii Ziemi LUBELSKIEJ im. Sw Jana z Dukli, I oddz. Chemioterapii
🇵🇱Lublin, Poland
Narodowy Instytut Onkologii im. Marii Sk?odowskiej-Curie - Pa?stwowy Instytut Badawczy
🇵🇱Warszawa, Poland
Unidade Local de Saude de Santa Maria, E.P.E. - Hospital de Santa Maria
🇵🇹Lisbon, Lisboa, Portugal
Hospital Senhora da Oliveira ? Guimaraes, E.P.E
🇵🇹Guimarães, Portugal
Champalimaud Cancer Center
🇵🇹Lisboa, Portugal
Hospital da Luz
🇵🇹Lisboa, Portugal
Instituto Português de Oncologia de Lisboa Francisco Gentil, E.P.E.
🇵🇹Lisbon, Portugal
Hospital Beatriz Angelo
🇵🇹Loures, Portugal
Centro Hospitalar do Porto ? Hospital de Santo António
🇵🇹Porto, Portugal
Instituto Portugues de Oncologia Do Porto Francisco Gentil Epe
🇵🇹Porto, Portugal
Centro Hospitalar de Vila Nova de Gaia / Espinho E.P.E
🇵🇹Vila Nova de Gaia, Portugal
Centro Hospitalar Trás Os Montes E Alto Douro EPE
🇵🇹Vila Real, Portugal
Spitalul Clinic de Obstetrica si Ginecologie Filantropia
🇷🇴Bucure?ti, Romania
Prof Dr I Chiricuta Institute of Oncology
🇷🇴Cluj-napoca, Romania
Medisprof SRL
🇷🇴Cluj-Napoca, Romania
Oncology Center Sf. Nectarie
🇷🇴Craiova, Romania
Onco Clinic Consult SA
🇷🇴Craiova, Romania
Institutul Regional de Oncologie Iasi
🇷🇴Iasi, Romania
Timisoara Emergency County Clinical Hospital
🇷🇴Timi?oara, Romania
Institute for Oncology and Radiology of Serbia
🇷🇸Belgrade, Serbia
University Hospital Medical Center Bezanijska kosa
🇷🇸Belgrade, Serbia
Health Center Kladovo
🇷🇸Kladovo, Serbia
Oncology Institute of Vojvodina
🇷🇸Sremska Kamenica, Serbia
General Hospital Djordje Joanovic - Zrenjanin
🇷🇸Zrenjanin, Serbia
Univerzitna nemocnica s poliklinikou Milosrdni bratia spol s r o
🇸🇰Bratislava, Slovakia
Onkologicky ustav sv. Alzbety, s.r.o.
🇸🇰Bratislava, Slovakia
Narodny onkologicky ustav
🇸🇰Bratislava, Slovakia
Vychodoslovensky onkologicky ustav
🇸🇰Košice, Slovakia
Institute of Oncology Ljubljana
🇸🇮Ljubljana, Slovenia
Cape Town Oncology Trials
🇿🇦Cape Town, South Africa
Cancercare Rondebosch Oncology
🇿🇦Cape Town, South Africa
WITS Clinical Research Site PPDS
🇿🇦City Of Johannesburg, South Africa
Sandton Oncology Medical Group (Pty) Ltd
🇿🇦City Of Johannesburg, South Africa
Excellentis Clinical Trial Consultants
🇿🇦George, South Africa
Medical Oncology Centre of Rosebank
🇿🇦Johannesburg, South Africa
Southern Cross Research South Africa (PTY) LTD
🇿🇦Mogale City, South Africa
Langenhoven Drive Oncology Centre
🇿🇦Port Elizabeth, South Africa
Wilgers Oncology Centre
🇿🇦Pretoria, South Africa
Eastleigh Breast Care Centre
🇿🇦Pretoria, South Africa
Hospital General Universitario de Elche
🇪🇸Elche, Alicante, Spain
ICO Badalona-H.U. Germans Trias i Pujol
🇪🇸Badalona, Barcelona, Spain
ALTHAIA Xarxa Assistencial de Manresa
🇪🇸Manresa, Barcelona, Spain
Corporacio Sanitaria Parc Tauli
🇪🇸Sabadell, Barcelona, Spain
Hospital HM Nuestra Señora de la Esperanza
🇪🇸Santiago de Compostela, Burgos, Spain
Hospital de Jerez
🇪🇸Jerez De La Frontera, Cadiz, Spain
Consorcio Hospitalario Provincial de Castellon
🇪🇸Castellon DE LA Plana/castello DE LA Plana, Castellon, Spain
Hospital Universitario Reina Sofia
🇪🇸Córdoba, Cordoba, Spain
Hospital Universitario de Donostia
🇪🇸Donostia, Guipuzcoa, Spain
Hospital Son Llatzer
🇪🇸Palma de Mallorca, Islas Baleares, Spain
Hospital Universitario A Coruña
🇪🇸Coruna, LA Coruna, Spain
CHUS H Clinico U de Santiago
🇪🇸Santiago de Compostela, LA Coruna, Spain
Hospital Universitario Insular de Gran Canaria
🇪🇸Las Palmas de Gran Canaria, LAS Palmas, Spain
Hospital Universitari Arnau de Vilanova
🇪🇸Lleida, Lerida, Spain
Hospital Universitario Fundación Alcorcón
🇪🇸Alcorcon, Madrid, Spain
Complejo Hospitalario de Navarra
🇪🇸Pamplona, Navarra, Spain
CHUVI ? H.U. Alvaro Cunqueiro
🇪🇸Vigo, Pontevedra, Spain
Hospital Nuestra Senora de Valme
🇪🇸Seville, Sevilla, Spain
Hospital Universitario Virgen Macarena
🇪🇸Seville, Sevilla, Spain
Hospital Universitari Sant Joan de Reus
🇪🇸Reus, Tarragona, Spain
Hospital Universitario de Canarias
🇪🇸S. Cristobal De La Laguna, Tenerife, Spain
Hospital Universitario Basurto
🇪🇸Bilbao, Vizcaya, Spain
Complejo Hospitalario Universitario de Albacete
🇪🇸Albacete, Spain
Hospital General Universitario de Alicante
🇪🇸Alicante, Spain
Hospital Universitario San Juan
🇪🇸Alicante, Spain
Hospital Nuestra Señora de Sonsoles
🇪🇸Avila, Spain
Hospital del Mar
🇪🇸Barcelona, Spain
Clinica Tres Torres
🇪🇸Barcelona, Spain
Hospital Universitario Quiron Dexeus
🇪🇸Barcelona, Spain
Hospital Clinic de Barcelona
🇪🇸Barcelona, Spain
Hospital de la Santa Creu i Sant Pau
🇪🇸Barcelona, Spain
Hospital de San Pedro de Alcantara
🇪🇸Caceres, Spain
Hospital Puerta del Mar
🇪🇸Cadiz, Spain
Institut Catala d'Oncologia Girona
🇪🇸Girona, Spain
Hospital Universitario Clínico San Cecilio
🇪🇸Granada, Spain
Hospital Universitario Virgen de Las Nieves
🇪🇸Granada, Spain
Hospital Universitario Juan Ramon Jimenez
🇪🇸Huelva, Spain
Hospital Universitario de Jaen
🇪🇸Jaen, Spain
Hospital General Universitario Gregorio Marañon
🇪🇸Madrid, Spain
IOB Madrid Institute of Oncology Hospital Beata Maria Ana de Jesus
🇪🇸Madrid, Spain
Hospital Universitario La Paz
🇪🇸Madrid, Spain
Clinica Universidad Navarra
🇪🇸Madrid, Spain
Hospital Universitario Infanta Leonor
🇪🇸Madrid, Spain
MD Anderson Cancer Center Madrid ? Espana
🇪🇸Madrid, Spain
Hospital Universitario Ramon y Cajal
🇪🇸Madrid, Spain
Hospital Clinico San Carlos
🇪🇸Madrid, Spain
Hospital Universitario Fundacion Jimenez Diaz.
🇪🇸Madrid, Spain
Hospital Universitario 12 De Octubre
🇪🇸Madrid, Spain
Hospital Universitario HM Sanchinarro ? CIOCC
🇪🇸Madrid, Spain
Hospital Universitario Puerta de Hierro - Majadahonda
🇪🇸Madrid, Spain
Hospital Universitario de Fuenlabrada
🇪🇸Madrid, Spain
Hospital Universitario Virgen de la Victoria
🇪🇸Malaga, Spain
Hospital General Universitario Morales Meseguer
🇪🇸Murcia, Spain
Hospital Universitario Virgen de La Arrixaca
🇪🇸Murcia, Spain
Hospital Universitario Son Espases
🇪🇸Palma de Mallorca, Spain
Hospital Universitario Virgen del Rocío
🇪🇸Sevilla, Spain
Fundacion Instituto Valenciano de Oncologia (IVO)
🇪🇸Valencia, Spain
Hospital Clinico Universitario de Valencia
🇪🇸Valencia, Spain
Consorcio Hospital General Universitario de Valencia
🇪🇸Valencia, Spain
Hospital Universitari i Politecnic La Fe de Valencia
🇪🇸Valencia, Spain
Hospital Clinico Universitario de Valladolid
🇪🇸Valladolid, Spain
Hospital Universitario Miguel Servet
🇪🇸Zaragoza, Spain
Länssjukhuset Ryhov
🇸🇪Jönköping, Sweden
Södersjukhuset
🇸🇪Stockholm, Sweden
Universitätsspital Basel
🇨🇭Basel, Switzerland
Universitätsspital Bern
🇨🇭Bern, Switzerland
Hirslanden Salem-Spital
🇨🇭Bern, Switzerland
Kantonsspital Graubünden KSGR
🇨🇭Chur, Switzerland
Luzerner Kantonsspital LUKS
🇨🇭Luzern, Switzerland
Hirslanden Klinik St. Anna
🇨🇭Luzern, Switzerland
Kantonsspital St. Gallen
🇨🇭St. Gallen, Switzerland
Spital STS AG Thun - Berner Oberland
🇨🇭Thun, Switzerland
Kantonsspital Winterthur Medizin Pneumologie
🇨🇭Winterthur, Switzerland
Brust-Zentrum Zürich AG Seefeldstrasse 214 Zürich
🇨🇭Zürich, Switzerland
Hsin-Chu Branch of National Taiwan University Hospital
🇨🇳Hsinchu City, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
🇨🇳Kaohsiung City, Taiwan
Taipei Medical University Shuang Ho Hospital
🇨🇳New Taipei City, Taiwan
Changhua Christian Medical Foundation Changhua Christian Hospital
🇨🇳Changhua County, Taiwan
China Medical University Hospital
🇨🇳Taichung, Taiwan
National Cheng Kung University Hospital
🇨🇳Tainan, Taiwan
Chi Mei Medical Cente
🇨🇳Tainan, Taiwan
Koo Foundation Sun Yat-Sen Cancer Center
🇨🇳Taipei City, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Mackay Memorial Hospital - Taipei Branch
🇨🇳Taipei, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
Chang Gung Memorial Hospital - Linkou
🇨🇳Taoyuan City, Taiwan
Taichung Veterans General Hospital
🇨🇳Xitun Dist., Taiwan
Siriraj Hospital, Mahidol University
🇹🇭Bangkok Noi, Thailand
Chulalongkorn Hospital
🇹🇭Bangkok, Thailand
Ramathibodi Hospital
🇹🇭Bangkok, Thailand
Hacettepe Universitesi Tip Fakultesi Hastanesi
🇹🇷Ankara, Turkey
Ankara City Hospital
🇹🇷Ankara, Turkey
Akdeniz University Medical Faculty
🇹🇷Antalya, Turkey
Trakya University Medical Faculty
🇹🇷Edirne, Turkey
Istanbul University Cerrahpasa Medical Faculty Hospital
🇹🇷Fat?h, Turkey
T.C. Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin City Hospital
🇹🇷Istanbul, Turkey
Kocaeli Universitesi Tip Fakultesi Arastirma ve Uygulama Hastanesi
🇹🇷Kocaeli, Turkey
Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi
🇹🇷Samsun, Turkey
Izmir Medical Point Hospital
🇹🇷Izmir, Turkey
Baskent Universitesi - Adana Uygulama Ve Arastirma Merkezi
🇹🇷Sariçam, Turkey
Katip Celebi University- Izmir Ataturk Egitim ve Arastirma Hastanesi
🇹🇷Izmir, Turkey
Uganda Cancer Institute
🇺🇬Kampala, Uganda
St Francis Hospital Nsambya
🇺🇬Kampala, Uganda
SI Institute for general and urgent surgery n.a. V.T.Zaitseva of NAMS of Ukraine
🇺🇦Kharkiv, Kharkiv Governorate, Ukraine
Ac?badem Adana Hospital, Oncology Department
🇹🇷Seyhan/Adana, Turkey
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastirma Hastanesi
🇹🇷Yen?mahalle, Turkey
Acibadem Altunizade Hospital
🇹🇷Üsküdar, Turkey
Municipal Non-profit Enterprise Odessa Regional Clinical Hospital of Odessa Regional Council
🇺🇦Odesa, Kherson Governorate, Ukraine
Communal Non-Profit Enterprise Chernihiv Medical Center of Modern Oncology of CRC
🇺🇦Chernihiv, KIEV Governorate, Ukraine
Regional Municipal Non-Commercial Enterprise Bukovynian Clinical Oncology Center
🇺🇦Chernivtsi, KIEV Governorate, Ukraine
Clinic Verum Expert LLC
🇺🇦Kyiv, KIEV Governorate, Ukraine
Communal Nonprofit Enterprise Kyiv City Clinical Oncological Center
🇺🇦Kyiv, KIEV Governorate, Ukraine
Kyiv Regional Oncological Dispensary
🇺🇦Kyiv, Ukraine
Medical Clinical Research Center of Medical Center LLC Health Clinic
🇺🇦Vinnytsia, Ukraine
Royal Sussex County Hospital
🇬🇧Brighton, United Kingdom
Leicester Royal Infirmary
🇬🇧Leicester, United Kingdom
University College London Hospitals
🇬🇧London, United Kingdom
Nottingham City Hospital
🇬🇧Nottingham, United Kingdom
Royal Preston Hospital
🇬🇧Preston, United Kingdom