Paracetamol (Acetaminophen) In Stroke

Not Applicable

Completed

• Conditions: Acute stroke; Circulatory System; Cerebrovascular diseases

• Registration Number: ISRCTN74418480
• Lead Sponsor: Erasmus Medical Center (The Netherlands)

Brief Summary

1. 2003 protocol in Dutch in http://www.ncbi.nlm.nih.gov/pubmed/14574783 2. 2005 protocol in English in http://www.ncbi.nlm.nih.gov/pubmed/16109181 3. 2008 protocol correction in http://www.ncbi.nlm.nih.gov/pubmed/18983661 4. 2009 results in https://pubmed.ncbi.nlm.nih.gov/19297248/ (added 18/02/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2002-11-06
• Study Completion: 2008-09-01
• Last Update Posted: 1 March 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 1400

Inclusion Criteria

1. Clinical diagnosis of acute stroke
2. Possibility to start treatment within 12 hours from onset
3. Brain Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) within 24 hours
4. Age 18 years or older
5. Signed informed consent

Exclusion Criteria

Abody temperature lower than 36¡ãC or higher than 39¡ãC
A history of liver disease
Alcohol abuse
1. Liver enzymes increased above twice the upper limit of normal
2. Allergy to paracetamol
3. Significant pre-stroke impairment (more than three on the modified Rankin Scale [mRS])

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Dichotomised mRS (less than or equal to two: good outcome, more than or equal to six: poor outcome) at three months.

Secondary Outcome Measures

Name	Time	Method
<br> 1. Score on the Barthel index after two weeks<br> 2. Body temperature after 24 hours of treatment<br> 3. EuroQol-5D instrument at three months<br>