Movement Velocity Effect on Cortical Reorganization and Finger Function in Stroke

Phase 1

Completed

• Conditions: Stroke
• Interventions: Behavioral: Tracking training

• Registration Number: NCT01575366
• Lead Sponsor: University of Minnesota

Brief Summary

Aim 1. Determine whether higher-velocity finger tracking training improves hand function more than slower velocity training. Working hypotheses: The higher-velocity training will have significantly greater functional improvement compared to the lower-velocity training, as measured by standardized upper extremity functional tests (Jebsen Taylor test, Box \& Block Test, and Finger extension force test)

Aim 2. Ascertain whether higher-velocity finger tracking training differentially induces cortical reorganization as compared to lower-velocity finger tracking training.

Working hypotheses: The higher-velocity training will have significantly greater cortical reorganization compared to the lower-velocity training, as measured by:

1. TMS - increased amplitude of motor evoked potentials (MEP) from paretic extensor digitorum muscle in response to paired-pulse TMS to ipsilesional primary motor area (M1).

2. fMRI - increased volume of activation, signal intensity, and laterality of ipsilesional M1.

Aim 3. Explore whether the functional improvements correlate with the cortical reorganization. Working hypotheses: The functional improvements will correlate with the cortical reorganization.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2010-02
• Study First Submitted: 2012-03-19
• Study First Submitted QC: 2012-04-09
• Study First Posted: 2012-04-11
• Primary Completion: 2012-08
• Study Completion: 2012-08
• Status Verified: 2019-10
• Last Update Submitted: 2019-10-30
• Last Update Posted: 2019-11-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 5

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Slow tracking training	Tracking training	-
Fast tracking training	Tracking training	-

Primary Outcome Measures

Name	Time	Method
Hand function improvement	taken at weekly intervals for the whole study length, 20 weeks.	Jebsen Taylor test, Box \& Block Test, and Finger extension force test

Secondary Outcome Measures

Name	Time	Method
corticospinal excitability	taken at weekly intervals for the whole study length, 20 weeks.	TMS
cognitive function	at the beginning and at the end of the study, which are 1st and 20th week.

Trial Locations

Locations (1)

University of Minnesota; 🇺🇸 Minneapolis, Minnesota, United States