Can we Improve Mortality Prediction in Patients With Sepsis in the Emergency Department
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 67
- 试验地点
- 1
- 主要终点
- Can we better predict mortality in septic patients from the Emergency Department?
研究概览
简要总结
This study aims to identify the prognostic role of procalcitonin (PCT), soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1), the soluble form of the urokinase plasminogen activator receptor (suPAR), highly sensitive C-reactive protein (hs-CRP), Interleukin-6 (IL-6), and azurocidin 1 (AZU1) in 28-day mortality for patients with sepsis in Emergency Department.
详细描述
The levels of the specified biomarkers were measured upon patient arrival at the Emergency Department (ED) and analyzed their correlation with 28-day mortality. The values of these biomarkers were monitored over the initial three days following admission to the ED, aiming to explore their potential in guiding the de-escalation of antibiotic treatment. Considering their prognostic significance, the main goal is to develop a novel scoring system tailored for use in the emergency department setting.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Sepsis 3 Criteria
排除标准
- •individuals aged under 18 or above 90
- •pregnant women
- •individuals in custody or deprived of their liberty
- •patients with associated pathologies such as severe trauma
- •other types of shocks
- •acute stroke
- •pancreatitis myocardial infarction, pulmonary edema, status asthmatics, convulsions, drug overdose, those requiring emergency surgery
- •terminal stage of neoplastic disease
结局指标
主要结局
Can we better predict mortality in septic patients from the Emergency Department?
时间窗: 03.2024-05.2024
Evaluation of the prognostic role of : IL-6, sTREM-1, suPAR, AZU1, hsPCR and PCT in predicting 28-day mortality in Emergency Department
次要结局
未报告次要终点
研究者
Sonia Luka
Teaching Assistant PhD Student Sonia Luka
Iuliu Hatieganu University of Medicine and Pharmacy