NCT01658397已完成不适用
The Effect of Calorie Deprivation on Adipose Tissue Distribution
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- Change in Bone Marrow Adiposity over 10 day fasting period
研究概览
简要总结
In this study, we will be studying the effects of acute calorie deprivation (a 10-day fast) on bone marrow fat, other fat stores and bone parameters. We will be measuring changes in bone marrow fat using magnetic resonance spectroscopy and will use MRI to measure subcutaneous and visceral fat depots. Our hypothesis is that levels of bone marrow fat will increase after an acute fast.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women, ages 21-45 years
- •101-130% of ideal body weight as defined by the 1983 Metropolitan Life Insurance Height and Weight Tables
- •Normal thyroid function
- •Regular menses (women)
- •Normal liver transaminases
排除标准
- •Any disease known to affect bone metabolism, including untreated thyroid dysfunction, Cushing's syndrome, or renal failure
- •Any medication known to affect bone metabolism -- including systemic steroids or immunosuppressants -- within three months of the study, excluding estrogen and progestins. Patients receiving depot medroxyprogesterone (Depo-Provera) will be excluded from participating for six months after their last injections. Bisphosphonates must have been discontinued for at least one year before participation
- •Serum potassium <3.0 meq/L
- •Pregnant and/or breastfeeding (women)
- •Diabetes mellitus
- •Active substance abuse, including alcohol
- •Contraindications to MRI: cardiac pacemaker, metal implants, claustrophobia
结局指标
主要结局
Change in Bone Marrow Adiposity over 10 day fasting period
时间窗: Baseline, After 10 day fasting period
Bone marrow adiposity will be measured before and after the 10 day fast using magnetic resonance spectroscopy.
次要结局
未报告次要终点
研究者
Pouneh K. Fazeli, MD
Assistant Professor of Medicine
Massachusetts General Hospital
研究点 (2)
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