A comparison of the effects of ketamine versus propofol (sedation) on blood flow to the brain in patients of traumtic brain injury
Phase 2
- Conditions
- Health Condition 1: G936- Cerebral edema
- Registration Number
- CTRI/2023/07/055227
- Lead Sponsor
- Postgraduate Institute of Medical Education and Research Chandigarh
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.ASA physical status I-III
2.Marshall CT score more than 2
Exclusion Criteria
a)Patients with thrombocytopenia (platelet count less than 1 lac/mm3) or coagulopathy (INR >1.5)
b)Polytrauma with Injury severity Score more than 15
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cerebral Perfusion Pressure following initiation of sedation regimen till 48 hours of mechanical ventilation <br/ ><br> <br/ ><br>Timepoint: Cerebral Perfusion Pressure following sedation regimen will be assessed hourly for the first 12 hours, 2 hourly for the next 12 hours and 4 hourly till 48 hours of mechanical ventilation. <br/ ><br> <br/ ><br>
- Secondary Outcome Measures
Name Time Method 1.Time for resolution of raised ICPTimepoint: 72 hours;2.GOS-E at 3 months follow upTimepoint: 3 months after discharge