The Effect of Cocoa on Platelet Function Profiles in Patients
- Conditions
- Platelet Dysfunction
- Interventions
- Dietary Supplement: Cocoa
- Registration Number
- NCT04554901
- Lead Sponsor
- The University of The West Indies
- Brief Summary
The effects of chocolate on cardiovascular health are still a matter of debate. It can potentially favor cardiovascular health through the antioxidative effects of cocoa ingredients, such as polyphenols (present in dark but not white chocolate).
- Detailed Description
Epidemiologic studies have shown inverse associations between dietary polyphenols (present in dark chocolate and cocoa) and mortality from coronary heart disease. However, the basis for this protective association is uncertain. Food polyphenols such as in cocoa reportedly have antioxidant properties and decrease platelet function in vitro. The goal of the present study was to investigate whether the beneficial antioxidant effect of polyphenol-rich cocoa can induce an improvement of endothelial and platelet function in patients with stable coronary artery disease with known platelet hyperreactivity.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 25
- Patients with stable coronary artery disease.
- Patients > 18y of age.
- Patients with T2DM.
- Patients who already ingest any cocoa-based products.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Cocoa Cocoa 2-week, once-daily 70%, 50g cocoa bar manufactured by The UWI Cocoa Research Institute (14 bars)
- Primary Outcome Measures
Name Time Method P2Y12 Reaction Units 2-weeks P2Y12 Reaction Units pre- and post-Cocoa
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
The University of the West Indies
🇹🇹Saint Augustine, North, Trinidad and Tobago