Comparision between healing extraction socket with and without use of Autogenous Sticky dentin for Socket Preservation Following Tooth Extraction

Phase 2/3

Recruiting

• Conditions: Dental caries, unspecified,

• Registration Number: CTRI/2023/02/049420
• Lead Sponsor: DR ASHUTOSH AGARWAL

Brief Summary

·        After tooth extraction, the remaining socket heals from the apex toward the crest.

·        When no additives are placed into the socket at the time of the extraction, the soft-tissue infiltration at the crest often results in facial and crestal bone loss.

·        Most of the bone loss occurs during the first six months after the procedure. Afterward, the resorption rate progresses at a pace of 0.5–1% on average annually. Moreover, an estimated 50% of the alveolar bone width is lost within 12 months after the extraction, 30% of which occurs within the first 12 weeks.

·        Dimensional changes after tooth extraction often result in bone resorption that complicates placement of implants or traditional prosthesis.

·        Socket preservation is a surgical procedure, in which graft material or a scaffold is placed in a fresh extraction socket to preserve the alveolar ridge dimensions for a future prosthesis.

·        There are many techniques, like using autogenous, allogeneic, xenograft, and alloplast graft materials, to guide and assist specialized cellular components of the periodontium to participate in the regenerative process to preserve bone width and height of the alveolus.

·        At present, all extracted teeth are generally considered clinical waste and, therefore, are simply discarded.

·        Recently, several studies have reported that extracted teeth from patients, which undergo a process of cleaning, grinding, demineralization, and disinfection, can be a very effective graft to fill alveolar bone defects in the same patient.

·        Injectable platelet-rich fibrin (iPRF ) forms a dynamic fibrin gel embedding platelets, leukocytes, type 1 collagen (COL1), osteocalcin (OC), and growth factors and providing slow release of growth factors it also stimulate intrinsic tissue regeneration capacity by stimulating the proliferation of human mesenchymal stem cells (MSCs) by inducing osteogenic differentiation of MSCs

The dentin graft preparation done according to protocol given **by** **Dwivedi A, Kour M. A neoteric procedure for alveolar ridge preservation using autogenous fresh mineralized tooth graft prepared at chair side. Journal of Oral Biology and Craniofacial Research. 2020 Oct 1;10(4):535-41.**

·        After adequate local anaesthesia atraumatic extraction of tooth is done. Then tooth is cleaned with carbide bur removing all soft tissue debris if any.

·        Enamel is sectioned off from tooth by carbide bur and pulpal tissue is extirpated by endo hand files and root canal is cleaned and made pulp free.

·        Autogenous dentin graft is prepared by conventional grinder of 1500w

·        Graft is then demineralised and sterilised by 30%basic alcohol (combination of NAOH +ethyl alcohol ) for 10 mins

·        Graft is then washed twice in phosphate buffer saline and now Graft is ready.

·        5ml blood is withdrawn from patient for preparation of injectable PRF (iPRF) and dentin graft is placed into i-PRF forming **sticky dentin**

This sticky dentin is placed into extraction socket site and extraction socket is approximated by applying abgel sponge followed by suturing

thtThe purpose of study  is to evaluate and compare the radiographical vertical bone fill in self healing socket vs sticky dentin grafted socket.

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Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-03-06
• Study Start: 2023-10-02

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Adult patients, free of any known systemic illness (such as diabetes mellitus, hypertension, or on drugs like steroids) who agreed to participate.
• Periodontal sound toot that indicated for extraction due to trauma, root caries, iatrogenic errors.
• 18 to 60 years of age and able to sign an informed consent form.
• Maintainable oral hygiene.
• Who will be ready to have their progress followed for at least 4-months.

Exclusion Criteria

• Patients with systemic illness/systemic drugs that would affect postoperative healing.
• Patients with poor oral hygiene Periodontal compromised patients with severe bone loss Pregnancy or lactation Psychiatric illness, Unwillingness to return for the follow-up examination.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To Measure the Vertical Bone Fill In Healed Socket	TO Measure immediately After Extraction of Tooth and T4 Measure extraction Socket After 4 months

Secondary Outcome Measures

Name	Time	Method
TO EVALUATE CHANGES IN SOFT TISSUE	4 WEEKS AND 16 WEEKS

Trial Locations

Locations (1)

Government College of Dentistry Indore; 🇮🇳 Indore, MADHYA PRADESH, India

Government College of Dentistry Indore

🇮🇳Indore, MADHYA PRADESH, India

DR ASHUTOS AGARWAL

Principal investigator

9399039680

masterashutoshagarwal@gmail.com