Skip to main content
MedPathMedPath Home
Clinical Trials/NCT02869360
NCT02869360
Completed
Not Applicable

Pilot Study of Positron Emission Tomography (PET) Imaging: Correlations With Advanced Magnetic Resonance Imaging in Multiple Sclerosis

University of British Columbia1 site in 1 country14 target enrollmentOctober 2016
Share to TwitterShare to FacebookShare to LinkedInShare to Reddit
ConditionsMultiple Sclerosis

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Multiple Sclerosis
Sponsor
University of British Columbia
Enrollment
14
Locations
1
Primary Endpoint
Whole Brain PBR28 binding
Status
Completed
Last Updated
6 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

Traditional Magnetic Resonance Imaging (MRI) in Multiple Sclerosis (MS) has enabled clinicians to measure disease activity but there are inherent limitations. Clinical/radiographic dissociation can be seen in some patients and the abnormalities are not specific.

This pilot study is an opportunity to determine the relationship between quantitative advanced MRI measures and OCT with PET measurements of microglial activation and myelin health.

Registry
clinicaltrials.gov
Start Date
October 2016
End Date
October 2, 2019
Last Updated
6 years ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Philippe Beauchemin

Clinical Fellow

University of British Columbia

Eligibility Criteria

Inclusion Criteria

  • •Diagnosed with Multiple Sclerosis according to the 2011 McDonald criteria.
  • •Aged 18 to 60
  • •High or mixed affinity binder to rs6971 TSPO polymorphism

Exclusion Criteria

  • •Pregnant or breastfeeding
  • •Suffering from an unstable medical condition
  • •Have a neurological or ocular disorder other than MS
  • •Any contra-indications to MRI

Outcomes

Primary Outcomes

Whole Brain PBR28 binding

Time Frame: Baseline

Secondary Outcomes

  • Optical Coherence Tomography (RNFL thickness)(Baseline)
  • Myelin Water Imaging(Baseline)
  • Lesional PiB binding(Baseline)
  • MR Spectroscopy (Total NAA, NAA/Cr, mI)(Baseline)

Study Sites (1)

Loading locations...

Similar Trials

Unknown
Not Applicable
PET Study in Multiple SclerosisMultiple Sclerosis
NCT03787446University of British Columbia9
Not yet recruiting
Not Applicable
PET/MRI of Primary Sclerosing CholangitisPSC
NCT06252610Massachusetts General Hospital10
Completed
Not Applicable
Natural History of Multiple Sclerosis and Its MimickersNeurologic DisordersHealthy VolunteersMultiple Sclerosis
NCT02504840National Institute of Neurological Disorders and Stroke (NINDS)104
Completed
Not Applicable
Accurate Diagnosis of Multiple Sclerosis Using PET/MRMultiple Sclerosis
NCT04521439Ruijin Hospital49
Recruiting
Early Phase 1
rhPSMA-73 PET-MRI Imaging for the Detection of Prostate Cancer Among Men Who Are Otherwise Candidates for Active SurveillanceProstate AdenocarcinomaStage I Prostate Cancer AJCC v8Stage IIA Prostate Cancer AJCC v8Stage IIB Prostate Cancer AJCC v8
NCT05852041Northwestern University40