临床试验/NCT02869360

NCT02869360已完成不适用

Pilot Study of Positron Emission Tomography (PET) Imaging: Correlations With Advanced Magnetic Resonance Imaging in Multiple Sclerosis

University of British Columbia1 个研究点分布在 1 个国家目标入组 14 人开始时间: 2016年10月最近更新: 2019年10月3日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方: University of British Columbia
入组人数: 14
试验地点: 1
主要终点: Whole Brain PBR28 binding

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Traditional Magnetic Resonance Imaging (MRI) in Multiple Sclerosis (MS) has enabled clinicians to measure disease activity but there are inherent limitations. Clinical/radiographic dissociation can be seen in some patients and the abnormalities are not specific.

This pilot study is an opportunity to determine the relationship between quantitative advanced MRI measures and OCT with PET measurements of microglial activation and myelin health.

研究设计

研究类型: Observational
观察模型: Cohort
时间视角: Prospective

入排标准

年龄范围: 18 Years 至 60 Years（Adult）
性别: All
接受健康志愿者: 是

入选标准

•Diagnosed with Multiple Sclerosis according to the 2011 McDonald criteria.
•Aged 18 to 60
•High or mixed affinity binder to rs6971 TSPO polymorphism

排除标准

•Pregnant or breastfeeding
•Suffering from an unstable medical condition
•Have a neurological or ocular disorder other than MS
•Any contra-indications to MRI

结局指标

主要结局

Whole Brain PBR28 binding

时间窗: Baseline

次要结局

Optical Coherence Tomography (RNFL thickness)(Baseline)
Myelin Water Imaging(Baseline)
Lesional PiB binding(Baseline)
MR Spectroscopy (Total NAA, NAA/Cr, mI)(Baseline)

研究者

发起方

University of British Columbia

申办方类型

Other

责任方

Principal Investigator

主要研究者

Philippe Beauchemin

Clinical Fellow

University of British Columbia

研究点 (1)

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