Effect of Laparoscopic Operation on Rocuronium and Cisatracurium: Pharmacokinetic and Pharmacodynamic Analysis
Phase 4
Completed
- Conditions
- C.Delivery; Surgery (Previous), Gynecological
- Interventions
- Registration Number
- NCT02194855
- Lead Sponsor
- Fudan University
- Brief Summary
The investigators investigated whether laparoscopic versus open surgical approaches affected the pharmacokinetic and pharmacodynamic of a single bolus dose of rocuronium or cisatracurium.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 100
Inclusion Criteria
- American Society of Anesthesiology 1-2
- BMI 18-30 kg.m-2
- elective gynaecological operations under general anaesthesia
Exclusion Criteria
- cirrhosis
- hepatitis
- hepatoma
- heart failure
- arrhythmia
- renal dysfunction
- electrolyte disturbances
- acid-base imbalances
- neuromuscular disorders
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description laparoscopic operation on rocuronium rocuronium according different surgical type, all patients were divided into 2 groups: the laparoscopic surgery group and open surgery group.Each group were randomly assigned to the rocuronium group and cisatracurium group. conventional open surgery on cisatracurium cisatracurium according different surgical type, all patients were divided into 2 groups: the laparoscopic surgery group and open surgery group.Each group were randomly assigned to the rocuronium group and cisatracurium group. conventional open surgery on rocuronium rocuronium according different surgical type, all patients were divided into 2 groups: the laparoscopic surgery group and open surgery group.Each group were randomly assigned to the rocuronium group and cisatracurium group. laparoscopic operation on cisatracurium cisatracurium according different surgical type, all patients were divided into 2 groups: the laparoscopic surgery group and open surgery group.Each group were randomly assigned to the rocuronium group and cisatracurium group.
- Primary Outcome Measures
Name Time Method the blood flow in the right and middle hepatic veins up to 9 months Measurements of the blood flow in the right and middle hepatic veins were performed at baseline and 1,5, 10, 20, 30min after insufflation of carbon dioxide or incise the skin as well as 1 and 5 min after deflation or close the wound.
- Secondary Outcome Measures
Name Time Method the plasma Concentration of rocuronium and cisatracurium up to 9 months Venous blood samples (3 ml) were taken 2 min prior to and at 5,30, 60 min following administration of rocuronium/cisatracurium.The aim of the present was to study the blood concentration of rocuronium/cisatracurium in laparoscopic surgery compared with conventional open gynaecological surgery