Fatigability Compared Men and Women Induced According to the Distance Traveled on an Ultra-marathon in the Mountains
- Conditions
- Ultra-marathon Runners
- Registration Number
- NCT04025138
- Brief Summary
Acute physiological consequences of ultra-marathon running are still unknown, particularly in women. Some studies have suggested that the proportion of fatigue attributable to peripheral and central mechanisms varies between males and females; however, results are contradictory.
The results from the investigators of the present experiment in two studies conducted in 2009 and 2012 showed that:
* A large part of fatigue induced by a mountain ultra-marathon could be attributed to central fatigue in males and that,
* Females exhibited less peripheral fatigue in the plantar flexors than males did after a 110-km ultra-trail-running race.
According to the literature, there seems to be a plateau in fatigue after 12-15 hours of running.
- Detailed Description
Thus, the main purpose of the present project is to investigate whether sex differences in neuromuscular fatigue in plantar flexors depend on the distance (\> 100 km vs \< 60 km).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 75
- Subject listed in the race "2019 Mont Blanc Ultra Trail"
- Affiliates or beneficiaries of social security scheme
- Signed consent
- Subject having been injured in the previous 3 months
- Pregnant woman
- Chronic joint diseases
- Chronic or central neurological pathologies
- Taking neuroactive substances that can alter corticospinal excitability
- Contraindication to experimental procedures including Transcranial Magnetic Stimulation (TMS)
- Taking corticosteroids in the previous 3 months
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Variation (%) of the amplitudes of the electric shock 5 or 6 day before the race and 1 hour after Measured by the electrically evoked force after contraction in isometric mode of the plantar flexors
- Secondary Outcome Measures
Name Time Method Rate of hemoglobin (%) 5 or 6 day before the race and 1 hour after Measured by blood sample.
creatinine (mg/L) 5 or 6 day before the race and 1 hour after Measured by blood sample.
Number of white blood cells 5 or 6 day before the race and 1 hour after Measured by blood sample.
uric acid (mg/L) 5 or 6 day before the race and 1 hour after Measured by blood sample.
lactate (mg/L) 5 or 6 day before the race and 1 hour after Measured by blood sample.
Kinematic variable 5 or 6 day before the race and 1 hour after Measured by treadmill result.
Proteinuria-density urinary (mg/24h) 5 or 6 day before the race and 1 hour after Measured by urinary sample.
C reactive protein (CRP) (mg/L) 5 or 6 day before the race and 1 hour after Measured by blood sample.
Blood viscosity 5 or 6 day before the race and 1 hour after Measured by blood sample.
urea (g/L) 5 or 6 day before the race and 1 hour after Measured by blood sample.
Electrically evoked forces 5 or 6 day before the race and 1 hour after Analysis :
* Quantification of neuromuscular fatigue assessment;
* Evolution of race mechanics and the energy cost between males and females depending on the distance of the race.
Electrically evoked forces measures by neurostimulator in percentage (%).Voluntary maximum forces plantar flexors 5 or 6 day before the race and 1 hour after Analysis :
* Quantification of neuromuscular fatigue assessment;
* Evolution of race mechanics and the energy cost between males and females depending on the distance of the race.
Measured by voluntary maximum forces plantar flexors test (seat type Cybex) in percentage (%).Voluntary maximum forces knee extensors 5 or 6 day before the race and 1 hour after Analysis :
* Quantification of neuromuscular fatigue assessment;
* Evolution of race mechanics and the energy cost between males and females depending on the distance of the race.
Voluntary maximum forces knee extensors measures by seat type Cybex in percentage (%).Three-Modality Evoked Potentials (TMEPs) 5 or 6 day before the race and 1 hour after Analysis :
* Quantification of neuromuscular fatigue assessment;
* Evolution of race mechanics and the energy cost between males and females depending on the distance of the race.
Three-Modality Evoked Potentials (TMEPs) measures by magnetic stimulator in percentage (%).Force/Velocity Profile (FVP) 5 or 6 day before the race and 1 hour after Analysis:
* Quantification of neuromuscular fatigue assessment;
* Evolution of race mechanics and the energy cost between males and females depending on the distance of the race.
Measured Force/Velocity Profile (FVP) test: 2 sprints of 8 seconds on a cycle ergometer.ElectroMyoGraphic activity (EMG) 5 or 6 day before the race and 1 hour after Analysis :
* Quantification of neuromuscular fatigue assessment;
* Evolution of race mechanics and the energy cost between males and females depending on the distance of the race.
ElectroMyoGraphic activity (EMG) measures by electromyography. The EMG signal will be recorded with pairs of electrodes fixed with an adhesive tape bilaterally over the muscular belly.Number of red blood cell 5 or 6 day before the race and 1 hour after Measured by blood sample.
Transcranial Magnetic Stimulation (TMS) 5 or 6 day before the race and 1 hour after Analysis :
* Quantification of neuromuscular fatigue assessment;
* Evolution of race mechanics and the energy cost between males and females depending on the distance of the race.
Measured supraspinal activation level and cortical excitation by Transcranial Magnetic Stimulation (TMS) in percentage (%).Number of platelets 5 or 6 day before the race and 1 hour after Measured by blood sample.
Trial Locations
- Locations (1)
CHU Saint-Etienne
🇫🇷Saint-Étienne, France
CHU Saint-Etienne🇫🇷Saint-Étienne, France