The effects of grafting with dental biomaterials on the tooth-supporting tissues surrounding lower second molars following removal of impacted third molars in healthy young adults
- Conditions
- oss of periodontal attachment on distal aspect of mandibular second molar as a result of an impacted third molarLoss of periodontal attachment on distal aspect of mandibular second molar as a result of an impacted third molarOral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon
- Registration Number
- ACTRN12620000497909
- Lead Sponsor
- The University Of Queensland
- Brief Summary
Periodontal defects are associated with impacted wisdom teeth on the distal aspect of the second molar. These defects have been shown to persist even after wisdom tooth extraction. The study aimed to examine the additional periodontal healing benefits of grafting with Bio-Oss Collagen at the time of extraction. The patients recruited had severe pre-existing periodontal defects. The results showed no statistically significant bony healing improvement when grafting was performed. This was consistently shown when examined both two-dimensionally and three-dimensionally on the cone-beam CT scans. The study is limited by the high dropout rates and small sample size.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 42
• One or two unerupted mandibular third molars that are Class I or II and Position B or C on the Pell and Gregory scale with a Horizontal or Mesioangular (10-80 degrees) of the Winter classification
• Evidence of radiographic bone loss of more than 5mm from the cementoenamel junction to the crest of the alveolar bone on the distal aspect of the distal root of the adjacent second molar at time of initial examination due to an impacted wisdom tooth
• Able to tolerate extraction procedure: surgeon will determine this parameter
• Medically fit and well. Classified as American Society of Anaesthesiologist (ASA) Class I patient as a normal, healthy patient. (no medical illness e.g. diabetes, not smoking, low alcohol intake)
• Aged 18 – 45 years old
•Impacted third molars that are disto-angular impacted or require extensive surgery
•Patient has a history of diagnosed periodontitis disease (more than 2mm of clinical attachment loss)
•Patient currently has periodontal disease in any aspect of the mouth except periodontal breakdown associated with impacted third molars (mandibular or maxillary)
•Patient has lost more than 2mm of clinical attachment due to non-periodontal reasons
•Pathology that requires more than just extraction and primary wound closure
•Plaque index of 40% or more (indicating poor oral hygiene)
•Patients unwilling to return for all periodontal review appointment
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method A primary outcome measure will be the linear measurements between the cemento-enamel junction and the alveolar bone crest on the distal aspect of the second molar on the cone beam CT scan.[6 months after the extractions];A primary outcome measure will be volumetric bone infill measurements on the cone beam CT scan.[6 months after the extraction]
- Secondary Outcome Measures
Name Time Method Bleeding on probing between test and control sites. This will be measured by probing the periodontal pockets and waiting 15 seconds. A scoring system of 1 (present) and 0 (absent) will be used to measure bleeding on probing [6 months after the extraction];The probing pocket depths between test and control sites six months after healing. This will be assessed by periodontal probes. [6 months after the extractions];Patient reported outcomes: measuring pain levels between test and control sites on the visual analogue scale[6 months after the extraction];patient reported outcomes: measuring patient level satisfaction on the patient satisfaction questionnaire.[6 months post-operatively]