Effect of Different Antihypertensive Treatment on Serum Uric Acid in Newly Diagnosed Hypertensive Patients

• Conditions: Hypertension

• Registration Number: NCT04554069
• Lead Sponsor: Assiut University

Brief Summary

Assessment of the influence of different antihypertensive drugs on serum uric acid in newly diagnosed hypertension patients.

Detailed Description

Hypertension is the most common condition seen in primary care and leads to myocardial infarction, stroke, renal failure, and death if not detected early and treated appropriately.

Thiazide-type diuretics, angiotensin-converting enzyme (ACE) inhibitors and some of angiotensin-II receptor blockers (ARB) were reported to reduce renal excretion of urate and increased serum uric acid levels, Beta-blockers also elevate serum uric acid levels.

Hyperuricemia is a risk factor for cardiovascular diseases. Hyperuricemia was found to correlate with hypertension excluding the influence of other factors such as age and renal function. Furthermore, many studies found that hyperuricemia was independently associated with cardiovascular events in patients treated with antihypertensive drugs.

It is important to control serum uric acid levels in hypertensive patients treated with antihypertensive drugs in order to reduce the risk of gout and cardiovascular events. There is a gap in knowledge in studies showing the effect of antihypertensive drugs on serum uric acid in newly diagnosed hypertensive patients.

Study Timeline

• Study First Submitted: 2020-09-05
• Study First Submitted QC: 2020-09-13
• Study First Posted: 2020-09-18
• Status Verified: 2021-01
• Last Update Submitted: 2021-01-21
• Last Update Posted: 2021-01-22
• Study Start: 2021-06-01
• Primary Completion: 2022-01
• Study Completion: 2022-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 280

Inclusion Criteria

• All newly diagnosed hypertensive patients aged 30 years old and above will be invited to participate in this study

Exclusion Criteria

1. Patients below 30 years old.
2. Patients with kidney disease.
3. Patients who are taking medications known to increase SUA as (Thiazide and Loop diuretics, Salicylates, Cyclosporin use) or decrease the level of uric acid in the urine as (Allopurinol, Febuoxstate).

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The effect of different antihypertensive drugs on serum uric acid in newly diagnosed hypertension.	6 months from baseline	we will measure the change of the level of serum uric acid after 6 months from the treatment of antihypertensive durgs

Secondary Outcome Measures

Name	Time	Method
obesity	6 months from baseline	it will be measured by BMI (kg/m2)