Effect of Different Antihypertensive Treatment on Serum Uric Acid in Newly Diagnosed Hypertensive Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 280
- 主要终点
- The effect of different antihypertensive drugs on serum uric acid in newly diagnosed hypertension.
研究概览
简要总结
Assessment of the influence of different antihypertensive drugs on serum uric acid in newly diagnosed hypertension patients.
详细描述
Hypertension is the most common condition seen in primary care and leads to myocardial infarction, stroke, renal failure, and death if not detected early and treated appropriately.
Thiazide-type diuretics, angiotensin-converting enzyme (ACE) inhibitors and some of angiotensin-II receptor blockers (ARB) were reported to reduce renal excretion of urate and increased serum uric acid levels, Beta-blockers also elevate serum uric acid levels.
Hyperuricemia is a risk factor for cardiovascular diseases. Hyperuricemia was found to correlate with hypertension excluding the influence of other factors such as age and renal function. Furthermore, many studies found that hyperuricemia was independently associated with cardiovascular events in patients treated with antihypertensive drugs.
It is important to control serum uric acid levels in hypertensive patients treated with antihypertensive drugs in order to reduce the risk of gout and cardiovascular events. There is a gap in knowledge in studies showing the effect of antihypertensive drugs on serum uric acid in newly diagnosed hypertensive patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All newly diagnosed hypertensive patients aged 30 years old and above will be invited to participate in this study
排除标准
- •Patients below 30 years old.
- •Patients with kidney disease.
- •Patients who are taking medications known to increase SUA as (Thiazide and Loop diuretics, Salicylates, Cyclosporin use) or decrease the level of uric acid in the urine as (Allopurinol, Febuoxstate).
结局指标
主要结局
The effect of different antihypertensive drugs on serum uric acid in newly diagnosed hypertension.
时间窗: 6 months from baseline
we will measure the change of the level of serum uric acid after 6 months from the treatment of antihypertensive durgs
次要结局
- obesity(6 months from baseline)
研究者
Dalia Mahran
Professor of Public Health and Community Medicine
Assiut University