Carotid Artery Corrected Flow Time Measured by Ultrasonography as a Predictor of Hypotension After Induction of General Anesthesia

Withdrawn

• Conditions: General Anesthesia Induction for Elective Surgery
• Interventions: Procedure: ultrasonographic measurement of corrected flow time(FTc) in carotid artery

• Registration Number: NCT02891772
• Lead Sponsor: Yonsei University

Brief Summary

Hypotension often happens immediately after anesthetic induction. Particularly in 5-10 minutes after anesthetic induction it is reported to happen more frequently. Patients may have preexisting hypovolemia resulting from dehydration and impaired compensatory responses, which increase the risk. However, it is still challenging to assess intravascular volume status in spontaneously breathing patients before anesthetic induction. Recently, the measurement of corrected flow time in carotid artery was introduced as quite useful, simple and noninvasive for the evaluation of circulating blood volume. The aim of this study is to evaluate whether corrected carotid artery flow time as determined by ultrasonography in spontaneously breathing patients before general anesthesia can predict hypotension after induction.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-08
• Study First Submitted: 2016-08-31
• Study First Submitted QC: 2016-08-31
• Study First Posted: 2016-09-07
• Primary Completion: 2017-08
• Study Completion: 2017-08
• Status Verified: 2019-01
• Last Update Submitted: 2019-01-14
• Last Update Posted: 2019-01-16

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• adult patients (19-80 years of age) who were scheduled to undergo elective surgery under general anesthesia

Read More

Exclusion Criteria

• mean blood pressure < 70 mmHg before induction of general anesthesia
• Patients who have currently taken angiotensin-converting enzyme inhibitor
• Patients who have currently taken angiotensin receptor blocker
• the presence of carotid artery stenosis > 50%
• cardiac rhythm other than sinus
• unstable angina
• a left ventricular ejection fraction of < 40%
• severe vascular disease
• implanted pacemaker/cardioverter
• autonomic nervous system disorders
• anticipated difficult airway
• pregnancy

Read More

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Hypotension after anesthetic induction group	ultrasonographic measurement of corrected flow time(FTc) in carotid artery	Patients with hypotension after anesthetic induction

Primary Outcome Measures

Name	Time	Method
corrected flow time (FTc) in carotid artery	10 minutes before induction of general anesthesia.	the area under the receiver operating characteristics curve of corrected flow time in carotid artery measured by ultrasonography to predict hypotension after anesthetic induction

Trial Locations

Locations (1)

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine; 🇰🇷 Seoul, Korea, Republic of