Emotional Processing, Family Life, Friendship and Social Integration in Patients With Multiple Sclerosis

Not Applicable

Completed

• Conditions: Multiple Sclerosis
• Interventions: Other: Cognitive evaluation; Other: Clinical evaluation

• Registration Number: NCT02708927
• Lead Sponsor: University Hospital, Bordeaux

Brief Summary

In addition to the physical, cognitive and psychological symptoms experienced by individuals with Multiple Sclerosis (MS), there is new research which indicates that some individuals with MS have a deficit in emotional processing, specifically, facial affect recognition. Emotional processing is defined as "a central aspect of social cognition". Models of social cognition indicate that emotional processing is an essential component of interpersonal relationships. The failure to accurately perceive other's emotions has been shown to lead to difficulty in social relationships, misinterpreting other's affect, and consequently, inappropriate responding.

However, even though a significant number of individuals with MS have impairments in emotional processing, we do not yet have an understanding of how these impairments affect the social functioning of individuals with MS, including the impact of these deficits on family structure. It is well-known that MS impacts one's social functioning including factors such as employment, daily living activities and interpersonal relationships. Recently a strong correlation was observed between reduced social participation in MS and quality of life. There is evidence to suggest that emotional processing deficits lie at the heart of this reduced social participation in persons with MS, leading to decreased social functioning and thus reduced quality of life. However, to date, this hypothesis has not been tested.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-03-03
• Study First Submitted: 2016-03-10
• Study First Submitted QC: 2016-03-10
• Study First Posted: 2016-03-15
• Primary Completion: 2019-01-28
• Study Completion: 2019-01-28
• Status Verified: 2019-02
• Last Update Submitted: 2019-02-01
• Last Update Posted: 2019-02-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 91

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control	Cognitive evaluation	healthy subject
patient	Clinical evaluation	MS diagnosis according to McDonald criteria (Polman et al., 2005). Relapsing-remitting MS (RRMS) according to Lublin et al. (1996);
patient	Cognitive evaluation	MS diagnosis according to McDonald criteria (Polman et al., 2005). Relapsing-remitting MS (RRMS) according to Lublin et al. (1996);

Primary Outcome Measures

Name	Time	Method
Interaction between measures of emotional processing (z score) and functional measures of social interaction	At inclusion (day 0)	among the 3 groups (impaired MS, no impaired MS and HS)

Secondary Outcome Measures

Name	Time	Method
Correlation between measures of emotional processing with cognitive testing (z scores by domain) and cognitive functioning evaluated by significant other	At inclusion (day 0)	(BAFQ)
Correlation between measures of emotional processing and quality of life measures	At inclusion (day 0)	(MUSIQoL questionnaire).
Impact of the cognitive impairment on the relationship of emotional processing (z score) with interpersonal relationships (family, friendship, marital) and society integration and social functioning.	At inclusion (day 0)

Trial Locations

Locations (2)

CHU de Dijon; 🇫🇷 Dijon, France

CHU de Bordeaux; 🇫🇷 Bordeaux, France