Effects of the combination ketamine-dexmedetomidine in experimental pain.
- Conditions
- pain
- Registration Number
- EUCTR2007-005201-21-SE
- Lead Sponsor
- Karolinska University Hospital Huddinge, Department of Anaesthesiology and Intensive Care
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Authorised-recruitment may be ongoing or finished
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
Healthy volunteers over 18 years old
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
Exclusion Criteria
Intake of substances that influence the effects or side-effects of dexmedetomidine or ketamine.
Pain at the beginning of the trial (more than 0/10 on the visual analog scale, VAS).
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: To examine the effect of the combination of low doses dexmedetomidine and ketamine in relation to the effects of one of the drugs alone on experimental pain.;Secondary Objective: To examine if the combination of dexmedetomidine and ketamine influence ventilatory funktion and if the combination of these two drugs reduce the circulatory and sensorial sideeffects in relation to the sideeffects of the drugs given alone.;Primary end point(s): Pain (VAS), heartrate, blood pressure, respiratory rate, percutane oxygen saturation, mental funktion
- Secondary Outcome Measures
Name Time Method