NCT05763472招募中不适用
Molecular Landscape Involved in the Onset of Breast Cancer in Patients With Germline BRCA-1/2 Mutations, During or After Therapy With Platinum-based Agents and/or PARP-inhibitors for Ovarian Cancer
Fondazione Policlinico Universitario Agostino Gemelli IRCCS1 个研究点 分布在 1 个国家目标入组 10 人开始时间: 2022年3月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Breast somatic mutations
研究概览
简要总结
This study will investigate, in patients with germline BRCA-1/2 mutations and breast cancer, arising during and / or after treatment with platinum-based chemotherapy and / or with PARP-inhibitors for ovarian cancer, the presence of molecular alterations potentially involved in the mechanisms of resistance to antineoplastic treatment on breast and ovarian tumor tissue.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Written informed consent.
- •Age older than 18 years.
- •Germline BRCA1/2 mutation.
- •Histologically confirmed ovarian cancer treated with platinum-based chemotherapy and/or PARP inhibitors.
- •Histologically confirmed breast cancer occurred during or after therapy with platinum-based agents and/or PARP-inhibitors for ovarian cancer.
- •Availability of FFPE breast and ovarian tumor samples.
排除标准
- •Other malignancies in the last 2 years.
- •Prior chemotherapy or radiation therapy for other malignancies.
结局指标
主要结局
Breast somatic mutations
时间窗: 15 months
To describe the presence of somatic mutations on breast tumor tissue, in patients with breast cancer arising during or after treatment with platinum-based chemotherapy or PARP-inhibitors for ovarian cancer.
次要结局
- Ovarian somatic mutations(15 months)
研究者
研究点 (1)
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