Germline BRCA1 and BRCA2 Mutations in Jewish Women Affected by Breast Cancer

Completed

• Conditions: Breast Cancer
• Interventions: Other: Blood test; Other: Questionnaire

• Registration Number: NCT00590109
• Lead Sponsor: Memorial Sloan Kettering Cancer Center

Brief Summary

The purpose of this project is to further characterize inherited predisposition to breast cancer mediated by specific BRCA alleles (BRACA1 185delAG and 5382insC; BRCA2 6174delT) among Jewish women.

Detailed Description

Not available

Study Timeline

• Study Start: 1997-03
• Study First Submitted: 2007-12-26
• Study First Submitted QC: 2008-01-09
• Study First Posted: 2008-01-10
• Status Verified: 2021-12
• Primary Completion: 2021-12-22
• Study Completion: 2021-12-22
• Last Update Submitted: 2021-12-27
• Last Update Posted: 2021-12-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 383

Inclusion Criteria

• Patients are eligible for the study if they are over 18 years of age, identify their ancestry as Jewish (both Sephardic and Ashkenazi Jews are eligible), have or have had a diagnosis of breast cancer, and are able to give informed consent.
• Relatives, age 18 or older, of the patients who meet eligibility criteria above and are found to have a specific BRCA1 or BRCA2 mutation if they are able to give informed consent.

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
1	Blood test	-
1	Questionnaire	-

Primary Outcome Measures

Name	Time	Method
to further characterize inherited predisposition to breast cancer mediated by specific BRCA alleles among Jewish women.	through study completion, an average of 1 year

Trial Locations

Locations (1)

Memorial Sloan Kettering Cancer Center; 🇺🇸 New York, New York, United States