Evaluation of circulating tumour cells in patients with tumour free lymphnodes in oral tongue carcinoma

Recruiting

Conditions: Malignant neoplasm of tongue, unspecified,

Registration Number: CTRI/2022/03/041256

Lead Sponsor: Amrita Institute of Medical Sciences

Brief Summary: Annual estimated incidence of oral cancer is 2, 75,000 and out of these 2/3rds occurs in the developing countries. In India more than one million new oral cancer cases are being detected annually of which 92% are Oral Squamous Cell Carcinomas (OSCC). Cancers of floor of mouth and tongue constitute about 50 percent of oral cancers in India.It is found that individuals under the age of 35yr with oral cancer (OC) 52% had OTSCC with a higher male preponderance (2.3:1). Added to this were the facts that 40% of these young individuals did not report any abusive habits, had poor quality of life with high morbidity, and increased healthcare and social burden as the lower socio-economic strata were more afflicted.

Cancer metastasis has been a scorching topic for its high mortality and recent researches has shown that premetastatic niche and metastatic niche are the 2 crucial steps in cancer metastasis, assisting cancerous cells infiltration, survival, and colonization at target sites.This study focus on the concept of premetastatic niche and considering CTCs as potential metastatic seeds which can form metastatic colonization in future. Study will assign the role of the probability of Circulating Tumor Cells as a real time monitor of tumor evolution. It also guide in developing therapies to prevent or eradicate metastases before reaching an incurable stage. This may substantiate the efficacy of liquid biopsy (CTC) which is a noninvasive method.

This study ultimately aims in improving the survival rates and preventing the tumour metastasis .

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: All

Target Recruitment: 97

Inclusion Criteria

Tongue Squamous Cell Carcinoma with no previous history of treatment other than diagnostic biopsy.

Exclusion Criteria

Second Primary Tumours ,Recurrent Tumours.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Evaluation of circulating tumour cells and to compare with the molecular markers of tumour free lymphnodes	5ml of peripheral blood to be taken before surgery.

Secondary Outcome Measures

Name	Time	Method
Evaluate of circulating tumour cells and corelate with the prognosis of OTSCC patients	2 year follow up

Trial Locations

Locations (1): Amrita Institute of Medical Sciences
🇮🇳
Ernakulam, KERALA, India
Amrita Institute of Medical Sciences
🇮🇳Ernakulam, KERALA, India
Dr RajalakshmiG
Principal investigator
8606469099
drraji14@gmail.com