Perioperative Analgesic Manipulations to Mitigate Pain After Elective Lumbar Spinal Surgeries: A Prospective Case-controlled Study
Overview
- Phase
- N/A
- Intervention
- Lidocaine Hydrochloride
- Conditions
- Pain, Postoperative
- Sponsor
- Benha University
- Enrollment
- 75
- Locations
- 1
- Primary Endpoint
- Proportion of patients reporting at least a 50% reduction in pain (measured by Numerical Rating Scale) in post-Operative Follow up for Lumbar Spine Surgery.
- Status
- Completed
- Last Updated
- 5 months ago
Overview
Brief Summary
Perioperative pain management is crucial for patients undergoing elective lumbar spine surgery. Moderate to severe postoperative pain can significantly impact recovery, worsen patient outcomes, and potentially lead to chronic pain.
Opioids have traditionally been the mainstay of postoperative pain management. However, their use is associated with several adverse effects, including nausea, vomiting, respiratory depression, and the risk of developing chronic pain. To mitigate these risks, there is a growing emphasis on multimodal analgesic approaches that combine various non-opioid medications to provide effective pain relief.
Non-opioid analgesics, such as nonsteroidal anti-inflammatory drugs (NSAIDs), regional anesthesia techniques, and adjuvant medications, can be used to reduce opioid requirements and improve patient outcomes. By carefully selecting and combining these modalities, clinicians can optimize pain management strategies for individual patients, minimizing the need for opioids and their associated side effects.
Investigators
Azza Mahrous Shaffik
Clinical Lecturer of Anesthesia, Pain & ICU
Benha University
Eligibility Criteria
Inclusion Criteria
- •Patients who had LDD and required lumbar discectomy,
- •Patients are free of exclusion criteria and accepted to participate in the study.
Exclusion Criteria
- •The presence of other indications for spinal surgery;
- •Obesity of grade ≥II;
- •Patients of ASA grade \>II;
- •opioid dependence for preoperative pain;
- •The presence of other causes of preoperative pain;
- •The presence of preoperative psychiatric manifestations especially delirium and/or cognitive dysfunction;
- •The presence of contraindications for the use of the study drugs;
- •The presence of uncontrolled cardiac, renal, or hepatic disorders and essential hypertension.
Arms & Interventions
Group L
Intervention: Lidocaine Hydrochloride
Group D
Intervention: Dexmedetomidine
Group F
Intervention: Fentanyl Citrate
Outcomes
Primary Outcomes
Proportion of patients reporting at least a 50% reduction in pain (measured by Numerical Rating Scale) in post-Operative Follow up for Lumbar Spine Surgery.
Time Frame: 2 months
Value of non-opioid injection in Pain Reduction post operatively manifested by recurrence of pain.