Comparison of Analgesic Effect of Intrathecal Morphine and Buprenorphine as adjuvants to Bupivacaine for Major Gynaecological Surgery : a Prospective, Randomized Double Blinded study.
Phase 4
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2021/09/036710
- Lead Sponsor
- chettinad health city
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Major gynaecological surgeries
BMI <35Kg/m2
Height more than 150cm
Duration of surgery more than60min
Exclusion Criteria
Spine deformity
Patients not willing for spinal anaesthesia
Coagulopathy
local infection at site of injection
Increased intracranial pressure
Patient allergic or sensitive to local anaesthetic agents
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the duration of analgesia using Morphine and Buprenorphine as adjuvants to BupivacaineTimepoint: The duration of analgesia is noted for 24hrs from the time of injection of drug to the time when the patient complaints of pain
- Secondary Outcome Measures
Name Time Method To compare the associated side effectsTimepoint: Side effects are assessed hourly for 24hrs;To compare the haemodynamics between two groupsTimepoint: All haemodynamic parameters are measured 5min once for first half an hour after injecting drug then at an interval of 15 min for 4hrs.Then at an interval of 1hour for 12hrs .Then at an interval of 3hrs for 24 hours;To compare the onset and duration of motor blockadeTimepoint: The time for the onset of motor blockade is assessed immediately after giving spinal <br/ ><br>the total duration of the motor blockade is assessed till the motor effect regresses;To compare the onset and duration of sensory blockadeTimepoint: Onset of sensory blockade is assessed from immediately after giving spinal anaesthesia till it reaches the highest level;To compare the sedation between two groupsTimepoint: sedation is assessed hourly after injecting the drug for 12hrs