Cardiovascular Risk Factors in Overweight Adolescents

Not Applicable

Completed

• Conditions: Overweight; Obesity
• Interventions: Behavioral: Aerobic interval training; Behavioral: Multitreatment approach

• Registration Number: NCT00184236
• Lead Sponsor: Norwegian University of Science and Technology

Brief Summary

The aim of the present study was to determine the effects of either a multidisciplinary approach or intensity-controlled interval training on cardiovascular risk factors in overweight adolescents.

Detailed Description

Several approaches have been used to improve cardiovascular health status and quality of life in obese children and adolescents, without coming to a consensus decision. Recently, a few studies have determined the effects of exercise training and diet on endothelial function in overweight and obese children and adolescents. The main findings are that only a moderate amount of exercise training and diet changes improves or restores endothelial function. It is difficult, however, to asses the separate effects of the training and diet, particularly because none of the studies have used a homogenous exercise training regimen. Unanimously, better, but affordable prevention and treatment strategies to improve wide-scale health outcome are called upon to slow down the current epidemic of overweight. It is now well established that physical activity reduces, but does not currently prevent the epidemic of obesity from either reaching global proportions or taxing public health and economy. Despite the recent advances in understanding the responsible biology of improved cardiovascular health with exercise training, several lines of research questions are still unresolved. For instance, the optimal program, e.g. when to initiate, whom to prescribe exercise to, which exercise-intensity is required, and the actual design of the treatment program, remain by far yet to determine.

Study Timeline

• Study Start: 2005-02
• Study First Submitted: 2005-09-13
• Study First Submitted QC: 2005-09-13
• Study First Posted: 2005-09-16
• Primary Completion: 2008-02
• Study Completion: 2008-05
• Status Verified: 2017-03
• Last Update Submitted: 2017-03-29
• Last Update Posted: 2017-03-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 54

Inclusion Criteria

• Overweight and obese adolescents in the Trondheim area, referred to medical treatment at St. Olav's Hospital

Exclusion Criteria

• Any coexisting medical illnesses

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Aerobic interval training	Aerobic interval training	Aerobic interval training (AIT)
Multitreatment approach	Multitreatment approach	multitreatment approach (MTG)

Primary Outcome Measures

Name	Time	Method
VO2max change	3 months and 12 months	maximal oxygen uptake change

Secondary Outcome Measures

Name	Time	Method
Cardiovascular risk factors	2 years
endothelial function change	3 months and 12 months	measured as FMD (flow-mediated dilution) using high-resolution vascular ultrasound

Trial Locations

Locations (1)

The Norwegian University of Science and Technology; 🇳🇴 Trondheim, Sør-Trøndelag, Norway