Gastric emptying and gut hormone secretion in anorexia nervosa: effects of refeeding

Not Applicable

Completed

• Conditions: Anorexia nervosa; Starvation; Mental Health - Eating disorders; Diet and Nutrition - Other diet and nutrition disorders; Metabolic and Endocrine - Normal metabolism and endocrine development and function

• Registration Number: ACTRN12616000134426
• Lead Sponsor: niversity of Adelaide

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-02-05
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

Participants will include 30 adolescent females with AN (restricting sub-type) (age: 12-19 years) admitted to the Departments of Adolescent Medicine at the CHW and Westmead Hospital, as well as 30 healthy-weight (BMI between 25th and 75th percentiles), aged-matched adolescent female controls. Potential AN participants will meet the diagnosis of anorexia nervosa as per the Diagnostic and Statistical Manual of Mental Health Disorders (4th edition) criteria, and will only be studied once medically stable (i.e. Heart rate >50bpm overnight). Adolescent females must have also reached Tanner stage 3 of development.

Exclusion Criteria

1)significant GI disease or previous surgery
2)current medical instability
3)current use of any medications which may affect GI function, weight or appetite
4)diabetes mellitus
5)epilepsy
6)pre-existing cardiovascular/respiratory disease
7)any other significant illness as assessed by the investigator
8)pregnancy or lactation
9)current use of contraceptive medication (e.g. Depo-Provera, Norplant, hormone releasing IUD’s)
11)intake of > 20 g alcohol per day
12)smokers (cigarettes, cigars, marijuana)
13)donation of blood in the 12 weeks prior to enrolment in the study, and participants will also be instructed to abstain from donating blood for 12 weeks after study completion.
14)high performance athletes
15)unable to comprehend study protocol
16)participation in any other research project within the last 3 months
18)abnormal liver function tests
19)have iron or haemoglobin levels below the normal range, as assessed with a screening blood test on admission, and in the week prior to each study day, conducted as part of routine clinical care.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Rate of gastric emptying, as determined by 13C-Octanoic acid breath test in response to a mixed nutrient test meal.[Measured over 2 hours, every 5 minutes in the first hour, and every 15 minutes in the second hour, at the baseline assessment, and 1 and 2 weeks post-baseline.];Blood glucose response to a mixed nutrient test meal[Measured at t=0, 30, 60 and 120 minutes after the test meal, at the baseline study assessment as well as 1 and 2 weeks post-baseline.];PYY concentration in response to a mixed nutrient test meal.[Measured at t=0, 30, 60 and 120 minutes after the test meal, at the baseline study assessment as well as 1 and 2 weeks post-baseline.]