Evaluation of Magnesium effects on brain tumor surgery
Early Phase 1
- Conditions
- neoplasm of brain.Malignant neoplasm of brain (unspecified)
- Registration Number
- IRCT201204159475N1
- Lead Sponsor
- Vise-Challenger of research of Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
eligible patients for brain tumor craniotomy
exclusion criteria of the study:
- creatinine greater than 1.5 mg / dl
- Renal failure and nephrotic syndrome
- Heart rate below 60 beats per minute
- Severe metabolic disorders
- Coagulation disorders (coagulopathy)
- Myasthenia Gravis
- Previous use of magnesium
- Diabetes Mellitus
- Age over 60 or under 18
- GCS score less than 6
- Major cardiopulmonary disease
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method CRP. Timepoint: before intervention, before surgery, after surgery. Method of measurement: ELISA kit.;S100b protein. Timepoint: before intervention, before surgery, after surgery. Method of measurement: ELISA kit.
- Secondary Outcome Measures
Name Time Method eurological adverse reactions. Timepoint: After surgery up to 6 month. Method of measurement: Clinical evaluation by neurosurgeon or neurologist.;Pain and bleeding during and after surgery. Timepoint: During and after surgery. Method of measurement: Clinical evaluation by anesthesiologist.