To study role of Transforming growth factor regulator 4 gene in patients of oral red and white lesion and healthy oral tissue.
Not Applicable
- Conditions
- Health Condition 1: K132- Leukoplakia and other disturbancesof oral epithelium, including tongue
- Registration Number
- CTRI/2024/08/071863
- Lead Sponsor
- MGM Dental College and Hospital, Navi Mumbai
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Group I (control group)
1. Normal patients those who are willing to participate.
2. Age and sex matched cases of healthy oral mucosa
3. Patients undergoing periodontal flap surgeries
4. Patients undergoing 3rd molar Extractions
Group II (study group): Histopathological diagnosed cases of oral leukoplakia
Exclusion Criteria
Group I (control group)
1. Patients those who are not willing to participate.
Group II (study group):
1. White lesions other than clinic-histologically diagnosed leukoplakia cases.
2. Patients undergoing treatment for leukoplakia and OSCC.
3. Patients who are not willing to participate.
4.Patients with other established carcinomas
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To analyze and compare genomic expression of Transforming growth factor ß regulator 4 <br/ ><br>(TBRG4) mRNA by q-PCR in clinico-histopathologically diagnosed cases of oral <br/ ><br>leukoplakia and normal healthy mucosa.Timepoint: within 48 weeks
- Secondary Outcome Measures
Name Time Method To immunohistochemically analyze & compare proteomic expression of Transforming <br/ ><br>growth factor ß regulator 4 (TBRG4) in clinico-histopathologically diagnosed cases of oral <br/ ><br>leukoplakia & normal healthy mucosa.Timepoint: within 48 weeks