Prognostic Value of Plasma Biomarkers Among Patients With Hypertension

• Conditions: Hypertension

• Registration Number: NCT04107584
• Lead Sponsor: Beijing Institute of Heart, Lung and Blood Vessel Diseases

Brief Summary

Hypertension is the most important risk factor for cardiovascular and cerebrovascular diseases，and also a substantial public health problem. The purpose of the study is to investigate the association between plasma biomarkers and adverse outcomes in patients with hypertension.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-04-01
• Status Verified: 2019-09
• Study First Submitted: 2019-09-26
• Study First Submitted QC: 2019-09-26
• Last Update Submitted: 2019-09-26
• Study First Posted: 2019-09-27
• Last Update Posted: 2019-09-27
• Primary Completion: 2022-08
• Study Completion: 2022-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 600

Inclusion Criteria

• >18 years old
• In accordance with the diagnosis of hypertension (BP≥140/90mmHg)

Exclusion Criteria

• The exclusion Criteria for the study program were as follows:

Pregnancy, history of heart failure or left ventricular ejection fraction less than 40%, myocardial infarction within one month, percutaneous transluminal coronary angioplasty or coronary artery bypass grafting, cerebrovascular disease, severe liver disease, severe chronic renal failure (eGFR less than 30 mL/min/1.73 m2) in the past three months.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary mortality of hypertension	Through study completion, an average of 2 years	The incidence rate of primary mortality of hypertension

Secondary Outcome Measures

Name	Time	Method
Secondary outcomes of heart	Through study completion, an average of 2 years	The incidence rate of left ventricular hypertrophy, myocardial infarction, congestive heart failure, and arrhythmia
Secondary outcomes of brain	Through study completion, an average of 2 years	The incidence rate of stroke (include cerebral hemorrhage and cerebral ischemia
Secondary outcomes of kidney	Through study completion, an average of 2 years	The incidence rate of hypertensive renal injure and end-stage renal disease
Secondary outcomes of eyes	Through study completion, an average of 2 years	The incidence rate of hypertensive eye injure

Trial Locations

Locations (1)

Beijing Anzhen Hospital; 🇨🇳 Beijing, Beijing, China