The Effect of Gastric Bypass Surgery on Gut Hormones Related to Bone Remodeling and Intestinal Growth.

Completed

• Conditions: Bone Loss; Obesity
• Interventions: Other: Meal test and dexa scan

• Registration Number: NCT01700686
• Lead Sponsor: University of Copenhagen

Brief Summary

The overall purpose is to explore the link between the gut and the bones by investigating meal stimulated changes in the blood level of a number of hormones and markers related to intestinal growth and bone turnover in patients undergoing surgery for obesity (gastric bypass). The hormones will be measured in blood samples taken before and after surgery. The results are compared with changes in body weight and body composition as measured by DEXA scanning.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-10
• Study First Submitted: 2012-10-02
• Study First Submitted QC: 2012-10-02
• Study First Posted: 2012-10-04
• Primary Completion: 2014-09
• Study Completion: 2014-09
• Status Verified: 2014-12
• Last Update Submitted: 2014-12-16
• Last Update Posted: 2014-12-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

• Caucasians fulfilling the criteria for laparoscopic gastric bypass.
• BMI>40kg/m2.

Exclusion Criteria

• Pregnancy
• Chronic obstructive pulmonary disease
• Diabetes mellitus
• Chronic inflammatory bowel disease
• Major psychiatric disorder
• Drug abuse

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Obese subjects	Meal test and dexa scan	Meal test and dexa scan

Primary Outcome Measures

Name	Time	Method
Meal stimulated changes in gut hormones and bone markers.	Before surgery and 4 weeks and 6 months after surgery.

Secondary Outcome Measures

Name	Time	Method
Changes in bone mass and body composition.	Before surgery and 6 months after surgery.

Trial Locations

Locations (1)

Hospital of Roskilde-Koege, The University of Copenhagen; 🇩🇰 Koege, Denmark