Comparison of Etomidate, Propofol and Etomidate-propofol Combination in Terms of Effects on Haemodynamic Response to Intubation

Phase 4

Completed

• Conditions: Induction of Anaesthesia
• Interventions: Drug: etomidate-propofol; Drug: etomidate; Drug: propofol

• Registration Number: NCT02186990
• Lead Sponsor: T.C. ORDU ÜNİVERSİTESİ

Brief Summary

The purpose of this study is to evaluate the effect of propofol, etomidate and propofol-etomidate combination on hemodynamic responses during laryngoscopy and tracheal intubation and assess the adverse effect related to this drugs.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-05
• Study First Submitted: 2014-06-06
• Study First Submitted QC: 2014-07-07
• Study First Posted: 2014-07-10
• Status Verified: 2014-08
• Primary Completion: 2014-08
• Last Update Submitted: 2014-08-12
• Last Update Posted: 2014-08-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• between 18 - 65 age
• ASA I - II status
• elective surgery

Exclusion Criteria

• emergency surgery
• pregnancy
• alcohol and drug abuse
• HT and cardiovascular disease
• BMI > 25 kg/m2
• hypersensitivity against study drug
• sedative drug use in last month
• difficult intubation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
propofol	etomidate-propofol	-
etomidate	etomidate	-
propofol-etomidate	propofol	-

Primary Outcome Measures

Name	Time	Method
haemodynamic values	in ten minutes after intubation	e.g., heart rate, blood pressure (mean arterial pressure)

Secondary Outcome Measures

Name	Time	Method
adverse effect of study drugs	within in 30 minutes drug administration	e.g. myoclonus, injection pain, allergy, skin rash

Trial Locations

Locations (1)

Anesthesiology and Reanimation Dept. Ordu University Training and Research Hospital; 🇹🇷 Altınordu, Ordu, Turkey