Multicentric study of combination therapy of theophylline and tiotropium in COPD
- Conditions
- Chronic obstructive pulmonary disease (COPD)
- Registration Number
- JPRN-C000000367
- Lead Sponsor
- Graduate school of biomedical sciences, Hiroshima university, department of molecular and internal medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 100
Not provided
Patients for whom theophylline or tiotropium is contraindicated Patients who have used other long acting bronchodilator, other xanthine, and inhaled corticosteroid within 1 month Patients with asthma Patients who need persistant oxygen therapy Patients with respiratory infection within 1 month Patients with severe hepatic, renal, heart, hematologic abnormality Patients with active tuberculosis or pulmonary sequelae of tuberculosis Patients with cancer within 2 years. (excluding basal cell carcinoma) Patients with cystic fibrosis and bronchiectasis Patients who are or could be pregnant In addition to the above exclusion criteria, patients judged to be inadequate to participate in this study by their physician
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ung function test QOL (St George Respiratory Questionnaire)
- Secondary Outcome Measures
Name Time Method Blood concentration of theophylline Induced sputum