CTRI/2016/01/006530已完成不适用
Comparison of effect of etomidate with propofol on haemodynamics during modified electroconvulsive therapy .
Divya Mehta1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2014年11月25日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Mean Blood Pressure
研究概览
简要总结
The main aim of this study is to find an ideal induction agent for anaesthesia during modified electroconvulsive therapy .Etomidate has been found to prevent haemodynamic changes during seizure .It also increases seizure duration .The studies revealed that more is the seizure duration , more is the therapeutic efficacy of electroconvulsive therapy.An ideal anaesthetic agent should be able to minimise haemodynamic changes without significant effect on seizure duration. This study compares the effect of etomidate with propofol on haemodynamics as well as seizure duration .
研究设计
- 研究类型
- Interventional
- 分配方式
- Permuted block randomization, fixed
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients suffering from a mental disorder as per ICD 10 necessitating Electroconvulsive therapy decided by Consultant Psychiatrist.
- •ASA grade 1 and 2 patients BMI > 18 and <25 kg/m2.
排除标准
- •Patients with history of relevant drug allergy.
- •Patients with severe cardiovascular or neurological or respiratory disorder.
- •Patients with history of substance use or drug abuse.
结局指标
主要结局
Mean Blood Pressure
时间窗: Before induction , after administration of study drug , during seizure , 1 ,3,5 and 10 minutes after the seizure .
次要结局
- Diastolic Blood pressure(Before induction , after administration of study drug , during seizure , 1 ,3,5 and 10 minutes after the seizure)
- O2 saturation(SpO2)(Before induction , after administration of study drug , during seizure , 1 ,3,5 and 10 minutes after the seizure .)
- Heart rate(Before induction , after administration of study drug , during seizure , 1 ,3,5 and 10 minutes after the seizure .)
- Systolic Blood Pressure(Before induction , after administration of study drug , during seizure , 1 ,3,5 and 10 minutes after the seizure .)
- Motor seizure duration(Measured by stop watch by isolated arm technique.)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
4 期
Comparison of Etomidate Plus Propofol, Etomidate Alone on Induction of AnesthesiaSurgeryNCT03820388University of California, Davis75
尚未招募
不适用
Comparison of two anesthetic agents in electric shock therapy for psychiatric illnessesCTRI/2018/08/015218Samiksha kumari70
已完成
4 期
Comparison of Etomidate, Propofol and Etomidate-propofol Combination in Terms of Effects on Haemodynamic Response to IntubationInduction of AnaesthesiaNCT02186990T.C. ORDU ÜNİVERSİTESİ90
已完成
不适用
Comparison of the effects of three intravenous drugs (propofol,etomidate and a 1:1 mixture of propofol and etomidate) on blood pressure,heart rate during injection of study drug and on insertion of endotracheal tube inside trachea during general anaesthesia .CTRI/2017/08/009438Chettinad Hospital and Research InstituteKelambakkamChennai60
Unknown
不适用
Etomidate/Propofol Mixture or Propofol Monotherapy Use in Patients Undergoing General AnesthesiaEtomidate is Mixed With PropofolNCT03855267Guolin Wang200