Impact of Intermittent Hypoxia on Phagocytosis and Sepsis Outcomes: the Potential Role of Statin (Part III: Human Study in 2018-2019)
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Granuolocyte function
研究概览
简要总结
Patients with treatment-naive obstructive sleep apnea (OSA) who need continuous positive airway pressure (CPAP) therapy on clinical basis are included as well as healthy controls without OSA. 15 cc peripheral venous blood is drawn on the date of diagnosis of OSA and 3-6 months after CPAP therapy. Granulocytes are harvested and tested for its function, such as phagocytosis, reactive oxygen species (ROS) production and bacteria-killing ability.
详细描述
Patients with treatment-naive obstructive sleep apnea (OSA) who need continuous positive airway pressure (CPAP) therapy on clinical basis are included. Healthy controls without OSA are enrolled, too. 15 cc peripheral venous blood is drawn on the date of diagnosis of OSA and 3-6 months after CPAP therapy (not given to controls). Granulocytes are harvested and tested for its function, such as phagocytosis, reactive oxygen species (ROS) production and bacteria-killing ability.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •<OSA group>
- •Patients with treatment-naive obstructive sleep apnea (OSA) who need continuous positive airway pressure (CPAP) therapy on clinical basis
- •aged 20 years or older
- •Apnea-hypopnea index (AHI) at least 15/hour
- •Willing to participate this study <Control group>
- •Healthy controls without OSA
- •aged 20 years or older
- •AHI less than 5/hour
排除标准
- •<OSA group>
- •OSA patients who do not need continuous positive airway pressure (CPAP) therapy
- •OSA Patients have ever received CPAP or other treatment
- •aged less than 20 years
- •AHI at least 15/hour
- •Not willing to participate this study <Control group>
- •Apnea-hypopnea index (AHI) equals to or more than 5/hour
- •aged less than 20 years
- •Not willing to participate this study
结局指标
主要结局
Granuolocyte function
时间窗: 6-month
Granuolocyte function, such as such as phagocytosis, reactive oxygen species (ROS)
次要结局
未报告次要终点