Investigation of the effect of a single dose of stimulant medication (dexamphetamine 10mg or methylphenidate 20mg) on appetite and on fasting and postprandial levels of insulin, glucose, leptin and ghrelin in healthy adult volunteers.
Recruiting
- Conditions
- Appetite suppression on stimulant medication. This is the presumed reason for the weight loss that usually occurs when children with attention deficit hyperactivity disorder (ADHD) are treated with dexamphetamine or methylphenidate.Healthy adult volunteers.Mental Health - Other mental health disorders
- Registration Number
- ACTRN12607000138482
- Lead Sponsor
- Chief investigator Dr Alison Poulton
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
Fit and healthy
Exclusion Criteria
Current treament of medical condition, previous regular use of stimulant medication, history of substance abuse, BMI>30.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Insulin levels [At time 0 (fasted) and at 3 hours (after food). ];Glucose levels [At time 0 (fasted) and at 3 hours (after food). ];Leptin levels [At time 0 (fasted) and at 3 hours (after food). ];Ghrelin levels [At time 0 (fasted) and at 3 hours (after food). ];Amount of food consumed [At 1.5 - 2 hours];Effect of medication on performance of auditory vigilance test[At 2 - 3.5 hours]
- Secondary Outcome Measures
Name Time Method Subjective effect of medication on appetite[At 0, 1, 2 and 3 hours]