Evaluation of Root Coverage by Connective Graft and Different Root Conditioning Methods

Not Applicable

Completed

• Conditions: Gingival Recession
• Interventions: Procedure: citric acid plus tetracycline; Procedure: Control; Procedure: antimicrobial photodynamic therapy

• Registration Number: NCT03095378
• Lead Sponsor: University of Sao Paulo

Brief Summary

The aim of this study was to evaluate the effect of two root-conditioning agents used in conjunction with subepithelial connective graft technique on root coverage outcomes. One is citric acid plus tetracycline and the other is antimicrobial photodynamic therapy.

Detailed Description

Citric acid plus tetracycline has properties of root surface decontamination, surface demineralization and exposure of collagen fibers.

Antimicrobial photodynamic therapy has been widely used in Periodontics to obtain reduction of periodontopathogenic bacteria with absence of systemic side effects and minimal bacterial resistance. Also, it has properties of root demineralization and exposure of collagen fibers. These properties may enhance root coverage in procedures of subepithelial connective graft.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2014-03-10
• Primary Completion: 2017-02-10
• Status Verified: 2017-03
• Study Completion: 2017-03-10
• Study First Submitted: 2017-03-23
• Study First Submitted QC: 2017-03-23
• Last Update Submitted: 2017-03-23
• Study First Posted: 2017-03-29
• Last Update Posted: 2017-03-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

• Gingival recession - Miller's class I or II (2 to 5 mm of height) at least in one tooth
• Indication of root coverage by dentin hypersensitivity or esthetic

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Exclusion Criteria

• Smokers
• Pregnancy
• Systemic medication use that could impair wound healing or surgery procedure
• Systemic diseases as diabetes, uncontrolled hypertension, coagulation diseases, kidney diseases.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Citric acid plus tetracycline	citric acid plus tetracycline	Root treatment with 50% citric acid plus 10% tetracycline, pH1, passive application for 90s.
Control	Control	Root treatment with scaling and root planing.
Antimicrobial photodynamic therapy	antimicrobial photodynamic therapy	Antimicrobial photodynamic therapy with toluidine blue O (100ug/ml - 60s pre-irradiation - pH4) and red laser (660nm, 30 milliwatts, 45 joules per square centimeter, sweeping mode, 90s)

Primary Outcome Measures

Name	Time	Method
Total root coverage measured with a periodontal probe in mm	one year	Distance from cemento-enamel junction to gingival margin = 0 mm

Secondary Outcome Measures

Name	Time	Method
Keratinized mucosa width measured with a periodontal probe in mm	one year	Ideal if keratinized mucosa width \> 5mm
Dentin hypersensitivity measured by applying an air jet on teeth and patient fills up a visual analogue scale	one year	Ideal if scale = 0

Trial Locations

Locations (1)

Bauru School of Dentistry; 🇧🇷 Bauru, Sao Paulo, Brazil