Antioxidant and Anti-inflammatory Effects of Yogurt Enriched With Polyphenols

Not Applicable

Completed

• Conditions: Oxidative Stress; Inflammation
• Interventions: Other: Yogurt enriched with polyphenols; Other: Yogurt not enriched with polyphenols

• Registration Number: NCT02494739
• Lead Sponsor: University of Thessaly

Brief Summary

The purpose of this study is to investigate the possible antioxidant and anti-inflammatory effects of yogurt enriched with polyphenols after 2-week consumption by healthy individuals.

Detailed Description

Eighteen healthy adult volunteers of both sexes consumed yogurt (400g per day) enriched with polyphenols (10mg/100g yogurt) or yogurt (400g per day) not enriched with polyphenols for two weeks in a double-blind, crossover, randomized manner.There was a washout period of at least 10 days. Physiological data and blood samples were collected before and after consumption of each yogurt.

Study Timeline

• Study Start: 2015-05
• Primary Completion: 2015-06
• Study Completion: 2015-06
• Study First Submitted: 2015-06-25
• Study First Submitted QC: 2015-07-07
• Study First Posted: 2015-07-10
• Status Verified: 2016-01
• Last Update Submitted: 2016-01-31
• Last Update Posted: 2016-02-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

• Healthy individuals
• Non-smokers

Exclusion Criteria

• Current use of dietary supplements or drugs
• Metabolic disease
• Lactose intolerance
• Pregnant, pregnancy intention or breast feeding

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Yogurt enriched with polyphenols	Yogurt enriched with polyphenols	Two yogurts (400g) enriched with polyphenols (10mg/100g yogurt) per day, for two weeks.
Yogurt not enriched with polyphenols	Yogurt not enriched with polyphenols	Two yogurts (400g) not enriched with polyphenols per day, for two weeks.

Primary Outcome Measures

Name	Time	Method
Antioxidant effects	Two weeks	Indices of blood antioxidant status
Anti-inflammatory effects	Two weeks	Indices of inflammation in blood

Secondary Outcome Measures

Name	Time	Method
Total cholesterol levels	Two weeks
Body composition	Two weeks	Body fat percentage
Hydration	Two weeks	Urine specific gravity
Resting heart rate	Two weeks	Resting heart rate
Blood glucose levels	Two weeks
High Density Lipoprotein cholesterol levels	Two weeks
Blood pressure	Two weeks	Blood pressure at rest
Triglyceride levels	Two weeks

Trial Locations

Locations (1)

Department of Physical Education & Sport Science of the University of Thessaly; 🇬🇷 Trikala, Karyes, Greece