Clinical Value of Left Atrial Appendage Flow for Prediction of Successful Catheter Ablation for Persistent Atrial Fibrillation

Terminated

• Conditions: Persistent Atrial Fibrillation; Catheter Ablation
• Interventions: Other: a complete transesophageal echocardiography

• Registration Number: NCT01144858
• Lead Sponsor: Clinique Pasteur

Brief Summary

The purpose of this study was to determine whether left atrial appendage flow velocity, as determined using trans esophageal echocardiography (TEE), predicts the outcome after catheter ablation of persistent Atrial fibrillation( pAF).

Detailed Description

40 PAF patients underwent 3D mapping and ablation. A stepwise approach including circumferential pulmonary vein (PV) isolation, continuous complex-fractionated electrogram (CFE) ablation and linear ablation was performed by the same operator. The procedural end point was termination of persistent AF by catheter ablation, either by conversion directly to sinus rhythm or to atrial tachycardia. Left atrial appendage (LAA) peak flow velocities were measured with transesophageal echography and averaged within each RR interval of 10 consecutive cardiac cycles.

Study Timeline

• Status Verified: 2008-10
• Study Start: 2009-01
• Study Completion: 2009-12
• Study First Submitted: 2010-06-15
• Study First Submitted QC: 2010-06-15
• Last Update Submitted: 2010-06-15
• Study First Posted: 2010-06-16
• Last Update Posted: 2010-06-16

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• First-time radiofrequency catheter ablation for pAF. pAF was defined as continuous AF lasting longer than 1 month, resistant to either electrical or pharmacological cardioversion.
• Informed consent

Exclusion Criteria

• Severe valvular disease requiring surgery
• Valvular prosthesis
• Known severe coronary artery disease
• Atrial and/or ventricular thrombosis
• New York Heart Association functional class III to IV
• Cerebrovascular disease
• Pulmonary embolism
• Latent or manifest hyperthyroidism

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
patients with persistent atrial fibrillation ablation	a complete transesophageal echocardiography	-

Primary Outcome Measures

Name	Time	Method
termination of persistent AF by catheter ablation

Secondary Outcome Measures

Name	Time	Method
Recurrences of AF were therefore determined from holter monitoring at 3 and 6 months or 12 leads ECG in care of symptomatic palpitation with clinical interview.

Trial Locations

Locations (1)

Clinique Pasteur; 🇫🇷 Toulouse, 43-45 avenue de Lombez, France