High-Intensity-Training for Patients with Psychosis

Recruiting

• Conditions: F20; F21; F22; F23; F24; F25; F28; F29; Schizophrenia; Schizotypal disorder

• Registration Number: DRKS00029208
• Lead Sponsor: niversitätsklinikum Köln

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-06-15
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Individuals may participate if they have a diagnosed paranoid psychosis (F20-F29), are between 18 and 60 years of age, and give written informed consent to participate in the study.

Exclusion Criteria

- Pre-existing conditions of the heart or lungs,
- uncontrolled diabetes mellitus,
- pre-existing diseases affecting the immune system (autoimmune diseases, e.g. Hashimoto-Thyroiditis, Crohn's disease, ulcerative colitis, etc.), Thyroiditis, Crohn's disease, ulcerative colitis, etc.),
- rheumatological pre-existing diseases (e.g. rheumatism, arthritis, ankylosing spondylitis, etc.)
- acute thromboses,
- implants in the trained body regions (e.g. artificial joints, partial prostheses),
- metal implants in the head region (e.g. deep brain stimulator, fixed braces)
- Acute inflammation of muscles, tendons or joints,
- chronic infectious diseases (e.g. HIV, hepatitis)
- cardiac pacemaker,
- an acute back problem (e.g. herniated disc),
- fresh bone fractures in the trained body regions,
- stone disease of bile ducts and urinary tract,
- severe head injuries or operations (acute or ever),
- diseases affecting the muscles, joints or bones,
- diseases that may affect the brain (e.g. epilepsy, multiple sclerosis),
- addictive diseases,
- current pregnancy
- lack of German language skills
- an IQ below 70
- taking medication that can affect the function of the heart (e.g. beta-blockers)

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
pre and post:<br>psychiatric symptoms (PANSS questionnaire), cardio-respiratory fitness VO2peak (spiroergometry) and maximum strength (one repetition maximum)

Secondary Outcome Measures

Name	Time	Method
pre and post<br>functioning and depression (GAF and BDI questionnaires), hippocampal volume (MRI), neuropsychological testing, blood infection markers (CRP, IL-6, BDNF, TNF-alpha, GSH), heart rate variability, motivational task<br>