se of sunscreens with DNA repair components are more efficacious that sunscreen only in improving keratosis actinica patients clinical outcome after photodynamic therapy
Not Applicable
Completed
- Conditions
- Actinic keratosisSkin and Connective Tissue Diseases
- Registration Number
- ISRCTN12347628
- Lead Sponsor
- IFO Hospital (Italy)
- Brief Summary
2016 results in https://pubmed.ncbi.nlm.nih.gov/27167413/ (added 29/05/2020)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Presence of at least 5 AK lesions on the scalp
Exclusion Criteria
1. Presence of non-melanoma skin cancer lesions
2. Allergy to one of the components of study products
3. Xerodema pigmentosum
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Evolution of AK lesions after successful PDT, evaluated at baseline and at 1, 3 6 and 9 months after PDT
- Secondary Outcome Measures
Name Time Method eed for additional PDT procedure, evaluated at baseline and at 1, 3 6 and 9 months after PDT
Related Research Topics
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What molecular mechanisms underlie the efficacy of photolyase in DNA repair for actinic keratosis post-PDT?
How does a film-forming sunscreen with photolyase compare to standard sunscreens in preventing field cancerization recurrence?
Are there specific biomarkers that correlate with improved clinical outcomes in actinic keratosis patients using DNA repair agents after PDT?
What adverse events are associated with photolyase-containing medical devices in post-PDT skin care regimens?
What combination therapies involving DNA repair enzymes show promise in managing actinic keratosis compared to monotherapy sunscreens?