Treatment of severe hypertension in end-stage renal failure: Effect of renal denervation in dialysis patients and patients with renal transplant.
Phase 4
- Conditions
- high blood pressurehypertension1003843010057166
- Registration Number
- NL-OMON39799
- Lead Sponsor
- Albert Schweitzer Ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
Patients with a renal transplant or on dialysis with therapy resistent hypertension, as defined in current guidelines (SBP >160 mmHg with the use of >=3 antihypertensive medication).
Exclusion Criteria
Patient with a renal artery stent. Pregnant or pregnancy desire. Known allergy for iodine contrast. Age <18 year.
Patients with contraindication for MRI can participate. in these patients there will be no MRI examinations.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primary study outcome is the degree of blood pressure drop in 6 months after<br /><br>renal denervation. Measurements will be performed with ambulatory blood<br /><br>pressure measurement during 24 hours. Also changes in medication regimen will<br /><br>be registered. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Effect of renal denervation on cardiac mass and function. Changes in sympatic<br /><br>nerve activity measured by EMG of the nervus peroneus. Changes in hormonal<br /><br>levels related to blood pressure regulation.</p><br>