Vitamin D Supplementation Prevents Pneumonia in Institutionalized Elderly Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- prevalence of pneumonia
研究概览
简要总结
Pneumonia is the fourth leading cause of death and frequently occurs in institutionalized elderly people in Japan. Recently, several clinical and experimental studies have reported the importance of vitamin D in the regulation of immune functions and its deficiency is associated with susceptibility to some infections. In the present study, the investigators hypothesize that deficiency of serum vitamin D is associated with development of pneumonia, and supplementation of vitamin D may lower the incidence of pneumonia and prolong survival in institutionalized elderly subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects are more than 65 years old and were resident in the facility for at least 6 months.
- •Subjects have no conditions known to interfere with vitamin D metabolism.
排除标准
- •Subjects are excluded if they have:
- •renal failure
- •hepatic failure
- •hyper- or hypo-parathyroidism
- •HIV infection, or malignant diseases
- •Subjects are also excluded if they are taking corticosteroid, thiazide diuretics, or supplementary vitamins.
研究组 & 干预措施
Group A
Group A is identified as serum vitamin D level more than 16 ng/dl.
Group C
Group C is identified as serum vitamin D less than 16 ng/dl and is not supplemented with vitamin D3.
Group B
Group B is identified as serum vitamin D level less than 16 ng/dl and is supplemented with vitamin D3.
干预措施: Vitamin D3 (Dietary Supplement)
结局指标
主要结局
prevalence of pneumonia
时间窗: one year
次要结局
- all cause mortality(one year)