comparative evaluation of bone graft with a blood product and bone graft alone in treatment of bone defects created by gum diseases.

Not yet recruiting

• Conditions: Gingivitis and periodontal diseases, (2) ICD-10 Condition: R688||Other general symptoms and signs,

• Registration Number: CTRI/2021/03/031929
• Lead Sponsor: DR BHALCHANDRA THORAT

Brief Summary

Regeneration of lost structures has become the primary therapeutic goal in periodontics. The objectives of periodontal regenerative therapy are to reconstitute the bone, cementum and periodontal ligament on a previously diseased root surface. Numerous therapeutic modalities for restoring periodontal osseous defects have been investigated. Many of these procedures include the use of bone grafts and bone replacement materials. For the last few decades, demineralized freeze-dried bone allograft (DFDBA) has been used alone and in combination with other treatment modalities for periodontal regeneration. The presence of bone morphogenetic proteins contained within DFDBA aids in

mesenchymal cell migration, attachment, and osteogenesis.



To evaluate and compare clinically and radiographically the effect of Autologus injectable platelet–rich fibrin (iPRF) with demineralized freeze-dried bone allograft(DFDBA) v/s Normal saline with demineralized freeze-dried bone allograft(DFDBA)in the treatment of infrabony periodontal defect and its effecton clinical parameter like Plaque index,  Gingival index, Probing pocket depth and Clinical attachment level.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-03-19
• Last Update Posted: 2021-05-03

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Age group between 20-60years Diagnosis with chronic periodontitis Patients in good systemic health with no contraindication to periodontal surgery Patients having Intrabony defects with pocket depths of 5mm or more,intrabony defect of 3mm with radiographic evidence of vertical / angular bone loss in the affected sites.
• Involved teeth to be vital and with no endodontic lesion.

Exclusion Criteria

• One — wall osseous defects.
• Patients suffering from any systemic diseases or with compromised immune system.
• Patients who had received any type of periodontal therapy for the past 6 months Patients taking any immuno-suppressive drugs like corticosteroids.
• Patients with a known history of allergy to doxycycline or Chlorhexidine or any other medicine are used in the study.
• Patients showing unacceptable oral hygiene compliance during /after the phase I therapy.
• Patients taking any drug known to cause gingival enlargement.
• Pregnant and/or lactating mothers.
• Patients who were smokers or had tobacco in any other form.
• Endodontically treated teeth.
• Patient on anticoagulant therapy Patient with bleeding disorders.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Plaque index(SILNESS & LOE 1964)	baseline 1 month 3months and 6 months postoperatively.
Gingival index(LOE & SILNESS 1963)	baseline 1 month 3months and 6 months postoperatively.
Probing pocket depth(PPD)	baseline 1 month 3months and 6 months postoperatively.
Clinical attachment Level(CAL)	baseline 1 month 3months and 6 months postoperatively.

Secondary Outcome Measures

Name	Time	Method
Radiographic bone fill will be evaluated using intraoral periapical radiographs of the surgical site.	Radiographs will be taken immediatly post surgery and at six month post surgery

Trial Locations

Locations (1)

Nair hospital dental college; 🇮🇳 Mumbai, MAHARASHTRA, India

Nair hospital dental college

🇮🇳Mumbai, MAHARASHTRA, India

DR BHALCHANDRA THORAT

Principal investigator

7249590890

bmbt5691@gmail.com