Sub(acute) Neuropsychopharmacological Profiling of 2C-B Versus Psilocybin

Maastricht University0 个研究点目标入组 18 人开始时间: 待定最近更新: 2024年2月28日

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•1. Previous experience with at least one psychedelic substance (e.g., psilocybin, LSD, DMT,
•ayahuasca, psilocybe fungi =1 times) but not within the past three months.
•2. Aged between 18 and 40 years.
•3. Free from medication (any drug prescribed for a medical indication).
•4. The participant is, in the opinion of the investigator, generally healthy based on assessment of
•medical history, physical examination, vital signs, electrocardiogram (ECG), and the results of the
•haematology, clinical chemistry, urinalysis, serology, and other laboratory tests.
•5. A resting pulse and heart rate (as read on the ECG) =51 bpm and =100 bpm. For participants in
•good physical condition, the lower limit is =45 bpm.
•6. A resting systolic blood pressure =91 mmHg and =140 mmHg and a resting diastolic blood
•pressure =51 mmHg and =90 mmHg.
•7. Clinical laboratory test values within clinical reference ranges at screening. Borderline values
•may be accepted if they are, in the opinion of the investigator, clinically insignificant.
•8. Normal binocular visual acuity, corrected or uncorrected.
•9. Absence of any major medical, endocrine and neurological condition, as determined by the
•medical history, medical examination, electrocardiogram and laboratory analyses (haematology,
•clinical chemistry, urinalysis, serology).
•10. Normal weight, body mass index.
•11. Written informed consent.

•1. Previous experience of serious side effects to psychedelic drugs (anxiety or panic attacks).
•2. Use of medication (other than paracetamol).
•3. History of drug addiction (determined by the medical questionnaire, drug questionnaire and
•medical examination).
•4. Excessive alcohol consumption (>20 units a week).
•5. Excessive smoking (>20 cigarettes a week).
•6. Current or history of psychiatric disorder (determined by the medical questionnaire and
•medical examination).
•7. Hypertension (diastolic >90 mmHg; systolic >140 mmHg).
•8. Liver dysfunction (hepatitis, cirrhosis, cancer, biliary cholangitis, hemochromatosis, alcoholic
•liver disease, etc as determined by the medical examination).
•10. Renal insufficiency (as indicated by the medical examination).
•11. History of cardiac dysfunctions (arrhythmia, ischemic heart disease, etc).
•12. Pregnancy or lactation.
•13. For women: absence of reliable contraceptive measures.
•14. fMRI contraindications (pacemakers, metal implants, claustrophobia, permanent eye makeup).

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