NL-OMON50024已完成不适用
Sub(acute) Neuropsychopharmacological Profiling of 2C-B vs Psilocybin - Sub(acute) Profiling of 2C-B vs Psilocybin
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Previous experience with at least one psychedelic substance (e.g.,
- •psilocybin, LSD, DMT, ayahuasca, psilocybe fungi >=1 times) but not within the
- •past three months
- •Aged between 18 and 40 years
- •Free from medication (any drug prescribed for a medical indication)
- •The participant is, in the opinion of the investigator, generally healthy
- •based on assessment of medical history, physical examination, vital signs,
- •electrocardiogram (ECG), and the results of the haematology, clinical
- •chemistry, urinalysis, serology, and other laboratory tests
- •A resting pulse and heart rate (as read on the ECG) >=51 bpm and <=100 bpm. For
- •participants in good physical condition, the lower limit is >=45 bpm.
- •A resting systolic blood pressure >=91 mmHg and <=140 mmHg and a resting
- •diastolic blood pressure >=51 mmHg and <=90 mmHg.
- •Clinical laboratory test values within clinical reference ranges at
- •screening. Borderline values may be accepted if they are, in the opinion of the
- •investigator, clinically insignificant.
- •Normal binocular visual acuity, corrected or uncorrected
- •Absence of any major medical, endocrine and neurological condition, as
- •determined by the medical history, medical examination, electrocardiogram and
- •laboratory analyses (haematology, clinical chemistry, urinalysis, serology).
- •Normal weight, body mass index (weight/height2) between 19,5 and 28 kg/m2
- •Written informed consent
排除标准
- •Previous experience of serious side effects to psychedelic drugs (anxiety or
- •panic attacks)
- •Use of medication (other than paracetamol)
- •History of drug addiction (determined by the medical questionnaire, drug
- •questionnaire and medical examination)
- •Excessive alcohol consumption (>20 units a week)
- •Excessive smoking (>20 cigarettes a week)
- •Current or history of psychiatric disorder (determined by the medical
- •questionnaire and medical examination)
- •Hypertension (diastolic >90; systolic >140)
- •Liver dysfunction (hepatitis, cirrhosis, cancer, biliary cholangitis,
- •hemochromatosis
- •alcoholic liver disease, etc as determined by the medical examination)
- •Renal insufficiency (as indicated by the medical examination)
- •History of cardiac dysfunctions (arrhythmia, ischemic heart disease, etc)
- •Pregnancy or lactation
- •For women: absence of reliable contraceptive measures
- •fMRI contraindications (pacemakers, metal implants, claustrophobia, permanent
- •eye makeup)
研究者
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