Evaluation of brain perfusion by Tc-99m ECD SPECT/CT, plasma biomarker and cognition function in sleep obstructive apnea patients before and after treatment

Phase 4

• Conditions: obstructive sleep apnea syndrome (OSA)primary snore; obstructive sleep apnea syndrome (OSA); primary snore; Respiratory - Sleep apnoea

• Registration Number: ACTRN12612001311842
• Lead Sponsor: Show Chwan Memorial Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-12-19
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

moderate and severe degree obstructive sleep apnea patients
age: 20~60 years old

Exclusion Criteria

Patients with symptoms of present of other sleep disorder, history of receiving medical intervention for sleep-related breathing disorder, cognition deterioration, hypertension, cancer, use of psychoactive medication, history of head injury with conscious loss and structural brain abnormalities

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Tc-99m ECD brain perfusion SPECT/CT [3 months later after CPAP/surgery treatment];plasma biomarkers[3 months later after CPAP/surgery treatment];computerized cognition function test[3 months later after CPAP/surgery treatment]

Secondary Outcome Measures

Name	Time	Method
SF 36 for measuring quality of life[3 months later after CPAP/surgery treatment];Epworth Sleepiness Scale for evaluating the average daytime sleepiness[3 months later after CPAP/surgery treatment]