Train the sedentary brain: move smart to reduce the risk of dementia;Sub study: Alternating aerobic and strength exercise in APOEe4 carriers and non-carriers in early stage dementia: effects and dose-response relatio
Completed
- Conditions
- Alzheimer Disease10012272Dementia
- Registration Number
- NL-OMON41982
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 118
Inclusion Criteria
Age >= 65 years
Diagnosis of dementia
Visiting daycare at least three times a week
Able to perform the Timed Up & Go Test with or without assistive device
Mini Mental State Examination (Folstein and Folstein 1975) score > 10.
Exclusion Criteria
Wheelchair bound
Cardiovascular problems that limit physical activity
Brain trauma
Epilepsy
Progressive or terminal disease
Depression
History of alcoholism
Severe visual problems
Severe auditory problems
Problems with the Dutch language
Mental incompetence
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p> Main outcome measure is cognitive function, measured with neuropsychological<br /><br>tests.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary outcome measures are physical functioning measured with<br /><br>performance-based field tests, and ADLS, mood and quality of life, measured by<br /><br>questionnaire.</p><br>
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular pathways are modulated by alternating aerobic and strength exercise in APOEe4 carriers with early-stage dementia?
How does the combination of aerobic and strength exercise compare to standard pharmacological treatments in early-stage dementia patients?
Which biomarkers correlate with cognitive improvement in APOEe4 carriers versus non-carriers during exercise interventions?
What are the safety profiles and adverse event management strategies for high-intensity interval training in early-stage dementia patients?
Can alternating aerobic and strength exercise synergize with cholinesterase inhibitors to enhance cognitive outcomes in APOEe4 carriers?