Train the sedentary brain: move smart. The effects of an interactive cycling training on cognitive functioning in older persons with early stage dementia.

Completed

• Conditions: Dementia; Alzheimer Disease; 10012272

• Registration Number: NL-OMON42495
• Lead Sponsor: Geriatrie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 162

Inclusion Criteria

Diagnosis of dementia
Mini Mental State Examination (Folstein and Folstein 1975) score > 20
Clinical Dementia Rating (CDR) score 0.5 -1.0, and still capable to give informed consent
Having insufficient physical activity according to the ACSM guideline for older adults (maximum of 30 minutes five days a week moderate intensity)

Exclusion Criteria

Wheelchair bound
Use of specifically dementia targeted nutritional supplements (e.g. Souvenaid) within the last 3 months
Cardiovascular problems that limit physical activity
Serious neurological or orthopedic disorder that limit physical activity
Diagnosis of severe depression, bipolar disorder or psychotic disorder (DSM-IV)
Current alcohol or drug abuse (DSM-IV)
Problems with the Dutch language
Severe hearing or visual problems not able to correct with the use of a hearing
device/glasses

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Our primary outcome measure is change in executive functioning, before and<br /><br>after the training intervention, in the interactive cycling group. Executive<br /><br>function will be measured with neuropsychological tests. Furthermore verbal and<br /><br>visual-spatial memory will be assessed. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcome measures are physical functioning measured with<br /><br>performance-based tests, Brain Derived Neurothropic Factor (BDNF) measured via<br /><br>blood sample, prefrontal cortex activation measured with functional Near<br /><br>Infrared Spectroscopy (by fNIRS) and changes in activities of daily living<br /><br>(ADL), mood and quality of life, as measured by questionnaires</p><br>