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Clinical Trials/NCT00374530
NCT00374530CompletedNot Applicable

Headache Inducing Characteristics and Possible Changes in Cerebral Blood Flow After Administration of PGE2

Danish Headache Center1 site in 1 country12 target enrollmentStarted: August 1, 2006Last updated:
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Conditions
Drugs

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
12
Locations
1
Primary Endpoint
Headache
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

Before, during and after intravenous administration of PGE2 we score/measure headache, rCBF, blood flow in the middle cerebral artery and diameter of superficial temporal artery and correlate that to known pathophysiology of headache to see if PGE2 is involved in headache pathophysiology.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Crossover
Masking
Double

Eligibility Criteria

Ages
18 Years to 40 Years (Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • •Healthy volunteers

Exclusion Criteria

  • •Primary Headache, headache on the day of the investigation, hypertension, hypotension, pregnant/nursing, daily intake of medication (except oral contraceptives), Cardiovascular or CNS disease, drug/alcohol abuse, psychiatric disease

Outcomes

Primary Outcomes

Headache

Secondary Outcomes

  • rCBF, blood flow, diameter of STA/RA, HR, BP

Investigators

Sponsor Class
Other

Study Sites (1)

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