NCT01637662已完成不适用
Mechanisms and Biological Markers During Headache Induced by Natriuretic Peptides
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 6
- 试验地点
- 1
- 主要终点
- Headache intensity, mean velocity of blood flow in the middle cerebral artery (VmeanMCA), superfical temporal artery diameter, PetCO2, adverse events and vital signs were recorded at T-10, T0 and then every 10 min until 120 min after start of infusion.
研究概览
简要总结
To investigate headache score and accompanying symptoms during and after infusion of the natriuretic peptides.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers
- •Aged 18-40
- •50-100 kg
- •Fertile women must use safe contraceptives (IUD, oral contraceptives, surgical sterilisation and long lasting gestagen.
排除标准
- •Tension type headache more than once/month
- •Other primary headaches
- •Daily medication except contraceptives
- •Drug taken within 4 times the halflife for the specific drug except contraceptives
- •Pregnant or lactating women
- •Exposure to radiation within the last year
- •Headache within the last 24 hours before start of trial
- •Hypertension
- •Hypotension
- •Respiratory or cardiac disease
研究组 & 干预措施
Healthy subjects
Experimental
干预措施: Natriuretic peptides (Drug)
结局指标
主要结局
Headache intensity, mean velocity of blood flow in the middle cerebral artery (VmeanMCA), superfical temporal artery diameter, PetCO2, adverse events and vital signs were recorded at T-10, T0 and then every 10 min until 120 min after start of infusion.
时间窗: Every 10 min.
次要结局
- All subjects were asked to complete a headache diary every hour until 10 h after the discharge. The diary included headache characteristics and accompanying symptoms according to the International Headache Society (IHS 2004)(10 hours after discharge)
研究者
研究点 (1)
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